School of Life Sciences, Tianjin University, Tianjin, 300072, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Adv Mater. 2021 Jun;33(25):e2007488. doi: 10.1002/adma.202007488. Epub 2021 May 13.
Reactive oxygen species (ROS)-related therapeutic approaches are developed as a promising modality for cancer treatment because the aberrant increase of intracellular ROS level can cause cell death due to nonspecific oxidation damage to key cellular biomolecules. However, the most widely considered strategy, photodynamic therapy (PDT), suffers from critical limitations such as limited tissue-penetration depth, high oxygen dependence, and phototoxicity. Non-photo-induced ROS generation strategies, which are defined as Xdynamic therapies (X = sono, radio, microwave, chemo, thermo, and electro), show good potential to overcome the drawbacks of PDT. Herein, recent advances in the development of Xdynamic therapies, including the design of systems, the working mechanisms, and examples of cancer therapy application, are introduced. Furthermore, the approaches to enhance treatment efficiency of Xdynamic therapy are highlighted. Finally, the perspectives and challenges of these strategies are also discussed.
活性氧（ROS）相关的治疗方法被开发为癌症治疗的一种有前途的方式，因为细胞内 ROS 水平的异常增加会由于对关键细胞生物分子的非特异性氧化损伤而导致细胞死亡。然而，最广泛考虑的策略，光动力疗法（PDT），受到一些关键限制，如有限的组织穿透深度、高氧依赖性和光毒性。非光诱导 ROS 生成策略，定义为 X 动力学疗法（X = 声、 放射、 微波、 化疗、 热、 电），显示出很好的潜力来克服 PDT 的缺点。本文介绍了 X 动力学疗法的最新进展，包括系统的设计、工作机制以及癌症治疗应用的实例。此外，还强调了提高 X 动力学治疗效率的方法。最后，还讨论了这些策略的观点和挑战。
