Habas Khaled, Demir Eşref, Guo Chongye, Brinkworth Martin H, Anderson Diana
School of Chemistry & Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, UK.
Department of Medical Services and Techniques, Vocational School of Health Services, Medical Laboratory Techniques Programme, Antalya Bilim University, Antalya, Turkey.
Drug Metab Rev. 2021 Nov;53(4):604-617. doi: 10.1080/03602532.2021.1917597. Epub 2021 May 14.
The field of nanotechnology has allowed for increasing nanoparticle (NP) exposure to the male reproductive system. Certain NPs have been reported to have adverse consequences on male germ and somatic cells. Germ cells are the bridge between generations and are responsible for the transmission of genetic and epigenetic information to future generations. A number of NPs have negative impacts on male germ and somatic cells which could ultimately affect fertility or the ability to produce healthy offspring. These impacts are related to NP composition, modification, concentration, agglomeration, and route of administration. NPs can induce severe toxic effects on the male reproduction system after passing through the blood-testis barrier and ultimately damaging the spermatozoa. Therefore, understanding the impacts of NPs on reproduction is necessary. This review will provide a comprehensive overview on the current state of knowledge derived from the previous and research on effects of NPs on the male reproductive system at the genetic, cellular, and molecular levels.
纳米技术领域使得纳米颗粒（NP）对男性生殖系统的暴露日益增加。据报道，某些纳米颗粒会对男性生殖细胞和体细胞产生不良影响。生殖细胞是代际之间的桥梁，负责将遗传和表观遗传信息传递给后代。许多纳米颗粒对男性生殖细胞和体细胞有负面影响，最终可能影响生育能力或产生健康后代的能力。这些影响与纳米颗粒的组成、修饰、浓度、团聚和给药途径有关。纳米颗粒穿过血睾屏障并最终损害精子后，可对男性生殖系统产生严重毒性作用。因此，了解纳米颗粒对生殖的影响是必要的。本综述将全面概述以往关于纳米颗粒对男性生殖系统在基因、细胞和分子水平上影响的研究现状。
