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年轻的南印度儿童的肠道微生物群特征：儿童性别特异性与生长的关系。

Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.

机构信息

Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.

Department of Pediatrics, USDA/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.

出版信息

PLoS One. 2021 May 14;16(5):e0251803. doi: 10.1371/journal.pone.0251803. eCollection 2021.

DOI:10.1371/journal.pone.0251803
PMID:33989353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8121364/
Abstract

Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth.

摘要

肠道微生物群被认为是儿童生长的调节剂。在这里，评估了 18-24 个月大的印度儿童的基于 16S rRNA 测序的粪便微生物群谱（n = 41），与他们的人体测量参数、肠道通透性、身体成分和总能量消耗有关。进行途径分析以评估与发育迟缓、体重不足和消瘦相关的微生物功能。粪便微生物群中富含普雷沃氏菌 9、双歧杆菌和大肠杆菌-志贺氏菌。体重、体重年龄 Z 评分（WAZ）和体重长度 Z 评分（WLZ）以及年龄是男孩（n = 23）中特定的微生物变异的协变量。长双歧杆菌亚种长双歧杆菌的丰度与 WAZ 呈正相关，而双歧杆菌双歧杆菌和短双歧杆菌的丰度与年龄呈负相关。脂多糖生物合成途径在发育迟缓（n = 16）和消瘦（n = 8）儿童中上调。这项研究的结果表明，儿童性别可能是肠道微生物群对儿童生长影响的关键调节剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/9d8be3f00868/pone.0251803.g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/83b591fcb1ca/pone.0251803.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/9d8be3f00868/pone.0251803.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/ed550fe6f0d0/pone.0251803.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/a69640466b8b/pone.0251803.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/d1a3cb78f7d2/pone.0251803.g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c879/8121364/9d8be3f00868/pone.0251803.g005.jpg

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