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Maturitas. 2019 Oct;128:49-52. doi: 10.1016/j.maturitas.2019.07.022. Epub 2019 Jul 30.
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Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients.经皮球囊扩张式主动脉瓣置换术治疗低危患者。
N Engl J Med. 2019 May 2;380(18):1695-1705. doi: 10.1056/NEJMoa1814052. Epub 2019 Mar 16.
3
2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2017年美国心脏协会/美国心脏病学会对2014年《美国心脏协会/美国心脏病学会瓣膜性心脏病患者管理指南》的重点更新:美国心脏病学会/美国心脏协会临床实践指南工作组报告
Circulation. 2017 Jun 20;135(25):e1159-e1195. doi: 10.1161/CIR.0000000000000503. Epub 2017 Mar 15.
4
Minimal Important Change and Minimal Detectable Change in Activities of Daily Living in Community-Living Older People.社区居住老年人日常生活活动中的最小重要变化和最小可检测变化
J Nutr Health Aging. 2017;21(2):165-172. doi: 10.1007/s12603-016-0797-8.
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Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients.经导管主动脉瓣置换术或外科主动脉瓣置换术治疗中危患者。
N Engl J Med. 2016 Apr 28;374(17):1609-20. doi: 10.1056/NEJMoa1514616. Epub 2016 Apr 2.
6
Patient-defined goals for the treatment of severe aortic stenosis: a qualitative analysis.患者定义的重度主动脉瓣狭窄治疗目标:一项定性分析
Health Expect. 2016 Oct;19(5):1036-43. doi: 10.1111/hex.12393. Epub 2015 Aug 14.
7
Predictors of poor outcomes after transcatheter aortic valve replacement: results from the PARTNER (Placement of Aortic Transcatheter Valve) trial.经导管主动脉瓣置换术后不良结局的预测因素:PARTNER(主动脉经导管瓣膜置换术)试验结果。
Circulation. 2014 Jun 24;129(25):2682-90. doi: 10.1161/CIRCULATIONAHA.113.007477. Epub 2014 May 23.
8
Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2).经导管主动脉瓣植入术更新的标准化终点定义:瓣膜学术研究联盟-2 共识文件(VARC-2)。
Eur J Cardiothorac Surg. 2012 Nov;42(5):S45-60. doi: 10.1093/ejcts/ezs533. Epub 2012 Oct 1.
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The evolving epidemiology of valvular aortic stenosis. the Tromsø study.主动脉瓣狭窄的不断演变的流行病学。特罗姆瑟研究。
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这值得吗?从患者角度看经导管主动脉瓣植入术的益处。

Was it worth it? Benefits of transcatheter aortic valve implantation from a patient's perspective.

作者信息

Beishuizen Sara J E, Festen Suzanne, van der Werf Hindrik W, de Graeff Pauline, van Munster Barbara C

机构信息

University Center of Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands.

Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

J Am Geriatr Soc. 2021 Sep;69(9):2605-2611. doi: 10.1111/jgs.17216. Epub 2021 May 14.

DOI:10.1111/jgs.17216
PMID:33989432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8518798/
Abstract

OBJECTIVES

Transcatheter aortic valve implantation (TAVI) is an important treatment option for patients with severe aortic stenosis. To improve patient selection, shared decision-making is recommended to elicit patients' treatment expectations and goals. We assessed patients' expectations and goals before TAVI treatment and whether these were met after treatment. Additionally, we evaluated how meeting these goals aligned with quality of life and functional recovery.

DESIGN

A mixed method study.

SETTING

An academic medical center.

PARTICIPANTS

Seventy-four patients undergoing TAVI between 2015 and 2017.

MEASUREMENTS

Patients' expectations and goals were assessed qualitatively before treatment. Six to twelve months post procedure, quality of life was measured with the EuroQuol-5D and any change in the number of dependencies in (instrumental) activities of daily living was assessed.

RESULTS

Mean age of patients was 81.5 years, and 37.8% were male. Regaining the ability to engage in a specific hobby or activity was the most important treatment goal (33 patients, 54.1%), followed by reducing symptoms (19 patients 31.1%). 66.2% of patients stated that their treatment goal was met. Quality of life was higher in this group, as compared with patients who had not met their treatment goal. Twenty-three patients (31.1%) showed functional improvement.

CONCLUSION

TAVI patients were quite capable of eliciting treatment goals and a majority stated, after treatment, that these had been met patients' experience of treatment benefits regarding these goals had poor alignment with functional outcomes. This raises questions regarding relevant outcome measurements in this population, and could aid in improving shared decision-making and patient selection for TAVI.

摘要

目的

经导管主动脉瓣植入术(TAVI)是重度主动脉瓣狭窄患者的重要治疗选择。为改善患者选择,建议采用共同决策以了解患者的治疗期望和目标。我们评估了TAVI治疗前患者的期望和目标,以及治疗后这些期望和目标是否得以实现。此外,我们还评估了实现这些目标与生活质量和功能恢复之间的一致性。

设计

一项混合方法研究。

地点

一家学术医疗中心。

参与者

2015年至2017年间接受TAVI治疗的74名患者。

测量方法

在治疗前对患者的期望和目标进行定性评估。术后6至12个月,使用欧洲五维健康量表(EuroQuol-5D)测量生活质量,并评估日常生活(工具性)活动中依赖数量的任何变化。

结果

患者的平均年龄为81.5岁,男性占37.8%。恢复参与特定爱好或活动的能力是最重要的治疗目标(33例患者,占54.1%),其次是减轻症状(19例患者,占31.1%)。66.2%的患者表示他们的治疗目标已实现。与未实现治疗目标的患者相比,该组患者的生活质量更高。23例患者(占31.1%)功能有所改善。

结论

TAVI患者相当能够明确治疗目标,且大多数患者在治疗后表示目标已实现,但患者在这些目标方面的治疗获益体验与功能结局的一致性较差。这引发了关于该人群相关结局测量的问题,并有助于改善TAVI的共同决策和患者选择。