Department of Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nuclear Medicine Research Center, Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Int Immunopharmacol. 2021 Jul;96:107741. doi: 10.1016/j.intimp.2021.107741. Epub 2021 May 11.
Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients. Despite the many advantages of this treatment, such as non-invasiveness, organ-preservation, and spatiotemporal flexibility in tumor targeting, it can lead to complications in irradiated healthy cells/tissues. In this regard, the use of radio-protective agents can alleviate radiation-induced complications. This study aimed to review the potential role of alpha-lipoic acid in the prevention/reduction of radiation-induced toxicities on healthy cells/tissues.
A systematic search was performed following PRISMA guidelines to identify relevant literature on the "role of alpha-lipoic acid in the treatment of radiotherapy-induced toxicity" in the electronic databases of Web of Science, Embase, PubMed, and Scopus up to January 2021. Based on the inclusion and exclusion criteria of the present study, 278 articles were screened. Finally, 29 articles were included in this systematic review.
The obtained results showed that in experimental in vivo models, the radiation-treated groups had decreased survival rate and body weight compared to the control groups. It was also found that radiation can induce mild to severe toxicities on gastrointestinal, circulatory, reproductive, central nervous, respiratory, endocrine, exocrine systems, etc. However, the use of alpha-lipoic acid could alleviate the radiation-induced toxicities in most cases. This radio-protective agent exerts its effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and so on.
According to the obtained results, it can be mentioned that co-treatment of alpha-lipoic acid with radiotherapy ameliorates the radiation-induced toxicities in healthy cells/tissues.
放射疗法是应用于 50-70%癌症患者的主要癌症治疗方式之一。尽管这种治疗有许多优点，如非侵入性、器官保留和肿瘤靶向的时空灵活性，但它会导致受照射的健康细胞/组织发生并发症。在这方面，使用放射保护剂可以减轻辐射引起的并发症。本研究旨在综述α-硫辛酸在预防/减少健康细胞/组织辐射诱导毒性中的潜在作用。
按照 PRISMA 指南进行系统检索，以确定电子数据库 Web of Science、Embase、PubMed 和 Scopus 中关于“α-硫辛酸在放射治疗诱导毒性治疗中的作用”的相关文献，检索时间截至 2021 年 1 月。根据本研究的纳入和排除标准，对 278 篇文章进行了筛选。最终，有 29 篇文章被纳入本系统评价。
研究结果表明，在实验性体内模型中，与对照组相比，放射治疗组的存活率和体重降低。还发现，辐射会引起胃肠道、循环系统、生殖系统、中枢神经系统、呼吸系统、内分泌系统、外分泌系统等轻度至重度毒性。然而，α-硫辛酸的使用在大多数情况下可以减轻辐射诱导的毒性。这种放射保护剂通过抗氧化、抗凋亡、抗炎等机制发挥作用。
根据研究结果，可以提到α-硫辛酸与放射疗法联合治疗可改善健康细胞/组织的辐射诱导毒性。
