Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
BMC Vet Res. 2024 Jul 5;20(1):293. doi: 10.1186/s12917-024-04134-4.
Senescence is accompanied by a progressive decrease in male reproductive performance, mainly due to oxidative stress and endothelial dysfunction. Alpha lipoic acid (ALA) is a potent antioxidant, that diffuses freely in aqueous and lipid phases, possessing anti-inflammatory and anti-apoptotic properties. This study aimed to examine the effects of supplemental dietary ALA on testicular hemodynamics (TH), circulating hormones, and semen quality in aged goats. Twelve Baladi bucks were divided into two groups (n = 6 each); the first fed a basic ration and served as a control group (CON), while the second received the basic ration supplemented with 600 mg ALA/ kg daily for consecutive eight weeks (ALA).
There were improvements in testicular blood flow in the ALA group evidenced by a lower resistance index (RI) and pulsatility index (PI) concurrent with higher pampiniform-colored areas/pixel (W3-W6). There were increases in testicular volume and decreases in echogenicity (W3-W5; ALA vs. CON). Compared to the CON, ALA-bucks had higher serum concentrations of testosterone, estradiol, and nitric oxide (W3-W5). There were enhancements in semen traits (progressive motility, viability, morphology, and concentration, alanine aminotransferase enzyme) and oxidative biomarkers (catalase, total antioxidant capacity, and malondialdehyde).
ALA dietary supplementation (600 mg/kg diet) improved aged bucks' reproductive performance by enhancing the testicular volume, testicular hemodynamics, sex steroids, and semen quality.
衰老伴随着雄性生殖性能的逐渐下降，主要是由于氧化应激和内皮功能障碍。α-硫辛酸（ALA）是一种有效的抗氧化剂，可自由扩散到水相和油相，具有抗炎和抗凋亡作用。本研究旨在研究补充膳食 ALA 对老年山羊睾丸血液动力学（TH）、循环激素和精液质量的影响。12 只 Baladi 公山羊分为两组（每组 6 只）；第一组喂基本日粮，作为对照组（CON），第二组喂基本日粮，每天补充 600mg/kg 的 ALA，连续 8 周（ALA）。
ALA 组睾丸血流改善，表现为阻力指数（RI）和搏动指数（PI）降低，同时精索彩色区域/像素（W3-W6）升高。睾丸体积增加，回声降低（W3-W5；ALA 与 CON）。与 CON 相比，ALA 组的血清睾酮、雌二醇和一氧化氮浓度升高（W3-W5）。与 CON 相比，ALA 组的精子特征（前向运动、活力、形态和浓度、丙氨酸氨基转移酶）和氧化生物标志物（过氧化氢酶、总抗氧化能力和丙二醛）得到改善。
膳食补充 ALA（600mg/kg 饮食）通过增加睾丸体积、睾丸血液动力学、性激素和精液质量来改善老年公山羊的繁殖性能。
