Ryu Seung-Hee, Park Eun-Young, Kwak Sungmin, Heo Seung-Ho, Ryu Je-Won, Park Jin-Hong, Choi Kyung-Chul, Lee Sang-Wook
Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Biomedical Sciences and Department of Pharmacology, Cell Dysfunction Research Center (CDRC), University of Ulsan College of Medicine, Seoul, Korea.
Oncotarget. 2016 Mar 29;7(13):15554-65. doi: 10.18632/oncotarget.6952.
Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-κB through inhibition of histone acetyltransferase activity. α-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.
放射性纤维化（RIF）是放射治疗最常见的晚期并发症之一。我们发现α-硫辛酸（α-LA）可有效预防RIF。在RIF小鼠模型中，采用腿部挛缩试验来检测α-LA的体内疗效。α-LA在体内和体外均能抑制照射后促纤维化基因的表达，并抑制TGF-β1介导的p300/CBP活性上调。因此，α-LA通过抑制组蛋白乙酰转移酶活性来抑制NF-κB的转录活性，从而预防放射性纤维化（RIF）。α-LA是一种可用于RIF预防治疗的新方法。
