抗菌药物对侵袭性细菌如化脓性链球菌和流感嗜血杆菌的疗效。
Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae.
机构信息
Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
出版信息
BMC Microbiol. 2021 May 14;21(1):148. doi: 10.1186/s12866-021-02217-y.
BACKGROUND
Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria.
METHODS
The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX).
RESULTS
Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective.
CONCLUSION
GRNX was the most effective agent against bacteria invading cells.
背景
复发性扁桃体炎是由细胞侵袭性细菌（如化脓性链球菌（S. pyogenes）和流感嗜血杆菌）引起的最常见的耳鼻喉科疾病之一。本研究旨在研究抗菌药物对细胞侵袭性细菌的作用。
方法
研究了五株非典型流感嗜血杆菌（NTHi）和四株化脓性链球菌（S. pyogenes）对 Detroit 562 细胞的细胞内侵袭。所用的抗菌药物为加雷沙星（GRNX）、克拉霉素（CAM）、阿莫西林（AMPC）、头孢地尼（CDTR-PI）和左氧氟沙星（LVFX）。
结果
NTHi 和 S. pyogenes 在 6 小时内完全侵袭 Detroit 562 细胞，对 CAM 的敏感性较低。GRNX、CAM 和 LVFX 对入侵细胞的细菌有效，但 AMPC 和 CDTR-PI 无效。GRNX 最有效。
结论
GRNX 是针对细胞内细菌最有效的药物。
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