咖啡摄入与老年 2 型糖尿病患者 CVD 危险因素的关系。
The relationship of coffee consumption and CVD risk factors in elderly patients with T2DM.
机构信息
Department of Food Science and Technology, Lahijan Branch, Islamic Azad University, Lahijan, Iran.
Department of Food Science and Technology, Roudehen Branch, Islamic Azad University, Roudehen, Iran.
出版信息
BMC Cardiovasc Disord. 2021 May 14;21(1):241. doi: 10.1186/s12872-021-02058-7.
OBJECTIVE
Clinical studies suggest increasing prevalence of cardiovascular disease (CVD) risk factors and diabetes among the elderly. Meanwhile, some food compounds, such as coffee, can also have beneficial effects on CVD risk factors. The aim of the present study was to examine the relationship between coffee consumption and CVD risk factors in the elderly with type 2 diabetes mellitus (T2DM).
METHODS
This cross-sectional study was performed during 2017 on 300 elderly people above 60 years of age with T2DM in Isfahan, Iran. Dietary assessment was performed using a food frequency questionnaire. Coffee consumption was classified into three groups including < 1, 1-3, and > 3 cups/day. Partial correlation test was used to investigate the relationship between CVD risk factors and usual coffee consumption.
RESULTS
The mean age and body mass index of participants were 70.04 ± 4.87 years and 24.74 ± 3.34 kg/m respectively. Coffee consumption had a significant inverse relationship with fasting plasma glucose (FPG) and diastolic blood pressure (DBP) in the elderly with T2DM (r: - 0.117, 0.134; p: 0.046, 0.022). Triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) had a significant positive relationship with coffee consumption levels (r: 0.636, 0.128; p: 0.028, 0.029). These results were obtained after controlling for potential confounders.
CONCLUSION
Increasing coffee consumption was linked to improved status of some CVD risk factors including FPG, HDL-C, and DBP in the elderly with T2DM. Nevertheless, increasing coffee consumption was also associated with higher TG level and had no significant effect on other risk factors. Further studies are required to confirm these results.
目的
临床研究表明，心血管疾病（CVD）风险因素和糖尿病在老年人中的患病率不断上升。与此同时，一些食物化合物，如咖啡，也对 CVD 风险因素有有益的影响。本研究旨在探讨 2 型糖尿病（T2DM）老年患者中咖啡摄入量与 CVD 风险因素之间的关系。
方法
本横断面研究于 2017 年在伊朗伊斯法罕对 300 名 60 岁以上患有 T2DM 的老年人进行。采用食物频率问卷评估膳食摄入情况。将咖啡摄入量分为 3 组，分别为 <1、1-3 和 >3 杯/天。采用偏相关检验研究 CVD 风险因素与习惯性咖啡摄入量之间的关系。
结果
参与者的平均年龄和体重指数分别为 70.04±4.87 岁和 24.74±3.34kg/m2。咖啡摄入量与 T2DM 老年患者的空腹血糖（FPG）和舒张压（DBP）呈显著负相关（r：-0.117、0.134；p：0.046、0.022）。甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）与咖啡摄入量呈显著正相关（r：0.636、0.128；p：0.028、0.029）。这些结果是在控制了潜在的混杂因素后得出的。
结论
增加咖啡摄入量与 T2DM 老年患者一些 CVD 风险因素的改善有关，包括 FPG、HDL-C 和 DBP。然而，增加咖啡摄入量也与更高的 TG 水平有关，对其他风险因素没有显著影响。需要进一步的研究来证实这些结果。
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