Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cardiovasc Diabetol. 2019 Apr 15;18(1):48. doi: 10.1186/s12933-019-0851-z.
The importance of triglycerides (TG) level as a risk factor for cardiovascular diseases (CVD) has been extensively investigated in the general population; however, their relationship in patients with type 2 diabetes mellitus (T2DM) is uncertain. We aimed to assess the association of TG with CVD in T2DM individuals.
We searched bibliographic databases for studies published until June 2018, reporting on the relationship between TG and CVD in T2DM people. A random-effects model with inverse variance weighting was used to compute pooled estimates of the most fully adjusted risk ratios (RR) and corresponding 95% confidence intervals (CI) according to TG categories, unit TG, and logarithm (log) of TG for CVD.
A total of 31 studies were included, involving 132,044 T2DM patients with 10,733 incident cardiovascular events. The pooled RR (95% CI) of CVD for an increase in baseline TG, log TG by 1-mmol/l and categorized in the highest vs. the lowest TG in T2DM were 1.06 (1.02, 1.09), 1.30 (1.18, 1.42) and 1.30 (1.16, 1.46), corresponding to a CVD risk increase of 6%, 30% and 30%, respectively. The pooled RR (95% CI) of CVD for per 1-mmol/L TG increment in eight studies and TG categories in three studies were 1.03 (0.98, 1.08) and 1.39 (0.92, 2.1) in T2DM patients adjusted for other lipids parameter, respectively.
In T2DM patients, an elevated triglyceride level cannot serve as an independent marker for an increased risk of cardiovascular events, but still, the higher serum TG levels tend to be associated with increased risks of CVD.
在普通人群中，甘油三酯（TG）水平作为心血管疾病（CVD）风险因素的重要性已得到广泛研究；然而，在 2 型糖尿病患者（T2DM）中的关系尚不确定。我们旨在评估 T2DM 个体中 TG 与 CVD 的相关性。
我们搜索了截至 2018 年 6 月发表的文献数据库，报告了 T2DM 人群中 TG 与 CVD 之间的关系。根据 TG 类别、单位 TG 和 TG 的对数（log），使用具有倒数方差加权的随机效应模型计算 CVD 的最充分调整风险比（RR）和相应的 95%置信区间（CI）的汇总估计值。
共纳入 31 项研究，共纳入 132044 例 T2DM 患者，发生 10733 例心血管事件。基线 TG 升高、log TG 增加 1mmol/L 和 TG 最高与最低分类时，T2DM 患者 CVD 的汇总 RR（95%CI）分别为 1.06（1.02，1.09）、1.30（1.18，1.42）和 1.30（1.16，1.46），相应的 CVD 风险分别增加 6%、30%和 30%。在调整了其他脂质参数后，在八项研究中每增加 1mmol/L TG 和在三项研究中的 TG 类别中，T2DM 患者的 CVD 汇总 RR（95%CI）分别为 1.03（0.98，1.08）和 1.39（0.92，2.1）。
在 T2DM 患者中，升高的甘油三酯水平不能作为心血管事件风险增加的独立标志物，但较高的血清 TG 水平仍与 CVD 风险增加相关。
