Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Department of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong SAR, China.
BMC Musculoskelet Disord. 2021 May 14;22(1):439. doi: 10.1186/s12891-021-04315-4.
Spondyloarthritis (SpA) has a significant impact on patients' quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for cost-utility analysis of health care interventions and calculation of quality-adjusted life-years. It has been validated in patients with SpA. However, its responsiveness property is unclear. Hence, the aim of study is to test the responsiveness properties of the EQ-5D health measure for Chinese patients with SpA.
Prospective and consecutive recruitment of 151 Chinese patients with SpA was conducted with follow-up assessments 6 months later. Demographic data including smoking and drinking habits, education level, income and occupation was collected. Disease-associated data including disease duration, presence of back pain, peripheral arthritis, dactylitis, enthesitis, uveitis, psoriasis, and inflammatory bowel disease was also recorded. Questionnaires regarding disease activity and functional disability (BASDAI, BASFI, BASGI, BASMI, ASDAS), mental health (HADS) and the EQ-5D scores were recorded. Responsiveness was tested against the global rating of change scale (GRC) and changes in disease activity using BASDAI and ASDAS-CRP.
A total of 113 (74.8%) patients completed the follow-up assessments. Most patients (61.6%) had low disease activity level with BASDAI <4 and 39.7% of patients had inactive disease by ASDAS-CRP. EQ-5D scores was well discriminated along with BASDAI and BASFI scores. EQ-5D scores also correlated well with HADS. The GRC was not able to discriminate adequately. No significant ceiling or floor effect was observed.
EQ-5D demonstrates satisfactory responsiveness property for assessment of changes in SpA disease activity.
II.
由于功能障碍，脊柱关节炎（SpA）对患者的生活质量有重大影响。通用健康工具，如欧洲五维健康量表（EQ-5D），对于医疗干预的成本效益分析和计算质量调整生命年很重要。它已在 SpA 患者中得到验证。然而，其反应度特性尚不清楚。因此，本研究旨在测试 EQ-5D 健康测量在中国 SpA 患者中的反应度特性。
前瞻性连续招募 151 例中国 SpA 患者，并在 6 个月后进行随访评估。收集人口统计学数据，包括吸烟和饮酒习惯、教育水平、收入和职业。还记录了与疾病相关的数据，包括疾病持续时间、背痛、外周关节炎、指（趾）炎、附着点炎、葡萄膜炎、银屑病和炎症性肠病。记录了疾病活动和功能障碍（BASDAI、BASFI、BASGI、BASMI、ASDAS）、心理健康（HADS）和 EQ-5D 评分的问卷。反应度通过全球变化评级量表（GRC）和 BASDAI 和 ASDAS-CRP 变化进行测试。
共有 113 例（74.8%）患者完成了随访评估。大多数患者（61.6%）的 BASDAI<4，疾病活动度低，39.7%的患者通过 ASDAS-CRP 患有不活跃疾病。EQ-5D 评分与 BASDAI 和 BASFI 评分很好地区分开来。EQ-5D 评分也与 HADS 密切相关。GRC 无法充分区分。未观察到明显的上限或下限效应。
EQ-5D 对评估 SpA 疾病活动的变化具有令人满意的反应度特性。
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