Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Department of Statistics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Sci Rep. 2021 May 14;11(1):10369. doi: 10.1038/s41598-021-89598-2.
Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have not been studied. Selected patients who received uniportal or multiportal VATS major lung resection were recruited. Blood samples were collected preoperatively and on postoperative days 1 and 3 for enzyme linked immunosorbent assay of serum levels of Tissue Inhibitor of Metalloproteinase (TIMP)-1, Insulin Growth Factor Binding Protein (IGFBP)-3, and Matrix Metalloproteinase (MMP)-9. A linear mixed-effects models were used to analyze the effects of uniportal VATS on the postoperative circulating chemokine levels. From March 2014 to April 2017, 68 consecutive patients consented for the prospective study and received major lung resection by either uniportal VATS (N = 29) or multiportal VATS (N = 39) were identified. Uniportal VATS major lung resection was associated with lower post-operative levels of TIMP-1 and MMP-9 compared to multiportal VATS after controlling for the effects of the corresponding baseline level and the time of follow-up measurement. No difference was observed for the level of IGFBP-3. Less immunochemokine disturbances was observed after uniportal VATS major lung resection compared to multiportal VATS.
多端口电视辅助胸腔镜手术 (VATS) 与开胸手术相比，在进行大肺切除时引起的免疫趋化因子产生较少。与多端口 VATS 相比，单端口 VATS 是否同样与术后早期循环中免疫趋化因子水平较低相关尚未研究。招募了接受单端口或多端口 VATS 大肺切除的选定患者。在术前和术后第 1 天和第 3 天采集血样，用于酶联免疫吸附法测定血清组织金属蛋白酶抑制剂 (TIMP)-1、胰岛素样生长因子结合蛋白 (IGFBP)-3 和基质金属蛋白酶 (MMP)-9 水平。使用线性混合效应模型分析单端口 VATS 对术后循环趋化因子水平的影响。从 2014 年 3 月至 2017 年 4 月，连续 68 例患者同意进行前瞻性研究，并接受了单端口 VATS（N=29）或多端口 VATS（N=39）的大肺切除术。在控制相应基线水平和随访测量时间的影响后，与多端口 VATS 相比，单端口 VATS 大肺切除术后 TIMP-1 和 MMP-9 的术后水平较低。IGFBP-3 水平无差异。与多端口 VATS 相比，单端口 VATS 大肺切除术后观察到免疫趋化因子紊乱较少。
