Department of Anesthesiology, Beijing Friendship Hospital of Capital Medical University, Beijing, China.
Department of Anesthesiology, Shengjing Hospital of China Medical University, Tiexi District, Huaxiang Road, Shenyang, Liaoning, China.
Sleep Breath. 2022 Mar;26(1):31-36. doi: 10.1007/s11325-021-02361-9. Epub 2021 May 14.
The cerebellum is widely regarded as a brain region involved in motor processing, non-motor processing, and even sleep-wake cycles. Cerebellar dysfunction may cause changes in the sleep-wake cycle, leading to sleep disturbances. At present, there is limited research on its effect on postoperative sleep after general anesthesia, despite the suspicion of its implication in postoperative sleep disturbances. With this review, we aim to provide a clear and comprehensive review of the cerebellar activity during the normal sleep-wake cycle, the correlation between cerebellar dysfunction and postoperative sleep disturbances, and the effects of general anesthesia on cerebellar dysfunction. Future large-scale multicenter trials are needed to objectively support the present results, identify the initial cerebellar dysfunction to prevent postoperative sleep disturbances, and develop new therapeutic measures targeting sleep disturbances with possible far-reaching implications for neurodegenerative diseases in general.
小脑被广泛认为是参与运动处理、非运动处理甚至睡眠-觉醒周期的脑区。小脑功能障碍可能导致睡眠-觉醒周期的改变，从而导致睡眠障碍。目前，尽管怀疑其与术后睡眠障碍有关，但对其在全身麻醉后术后睡眠影响的研究有限。通过本次综述，我们旨在对正常睡眠-觉醒周期中小脑活动、小脑功能障碍与术后睡眠障碍的相关性以及全身麻醉对小脑功能障碍的影响进行清晰全面的综述。需要未来进行大规模多中心试验来客观支持目前的结果，确定初始小脑功能障碍以预防术后睡眠障碍，并针对可能对一般神经退行性疾病产生深远影响的睡眠障碍开发新的治疗措施。
