Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Head Neck. 2021 Sep;43(9):2740-2754. doi: 10.1002/hed.26738. Epub 2021 May 14.
We aimed to investigate the preoperative C-reactive protein (CRP)-lymphocyte ratio (CLR) as a prognostic biomarker in oral cavity squamous cell carcinoma (OSCC).
Three hundred and sixteen patients with OSCC treated with curative surgery were retrospectively assessed and the receiver operating characteristic curve was used to evaluate the discriminative ability of inflammatory markers. The prognostic value of CLR was investigated with Cox proportional hazards analysis.
The CLR cutoff of 3.88 (p < 0.001) demonstrated optimal prognostic performance compared with other inflammatory combinations. A higher preoperative CLR (≥3.88) was significantly associated with clinicopathological aggressiveness and predicted unfavorable overall survival and disease-free survival (hazard ratios = 3.498 and 1.994, respectively; both p < 0.001). The CLR-based nomogram provided accurate survival prediction (concordance index: 0.803).
Preoperative CLR is a feasible prognostic biomarker in patients with OSCC, and the CLR-based nomogram might serve as prognostic tool in era of personalized medicine.
我们旨在研究术前 C 反应蛋白（CRP）-淋巴细胞比值（CLR）作为口腔鳞状细胞癌（OSCC）的预后生物标志物。
回顾性评估了 316 例接受根治性手术治疗的 OSCC 患者，并使用受试者工作特征曲线评估炎症标志物的鉴别能力。采用 Cox 比例风险分析研究 CLR 的预后价值。
与其他炎症组合相比，CLR 截断值为 3.88（p<0.001）显示出最佳的预后性能。较高的术前 CLR（≥3.88）与临床病理侵袭性显著相关，并预测总生存和无病生存不良（风险比分别为 3.498 和 1.994；均 p<0.001）。基于 CLR 的列线图提供了准确的生存预测（一致性指数：0.803）。
术前 CLR 是 OSCC 患者可行的预后生物标志物，基于 CLR 的列线图可能成为个性化医疗时代的预后工具。
