Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Head Neck. 2023 Jun;45(6):1558-1571. doi: 10.1002/hed.27372. Epub 2023 Apr 20.
We aimed to probe the hemoglobin-albumin-lymphocyte-platelet (HALP) score's prognostic value in oral cavity squamous cell carcinoma (OSCC).
Medical data of 350 patients with primary operated OSCC were retrospectively reviewed. We derived the optimal HALP cutoff by executing receiver operating characteristic curve analysis, and patients were then grouped based on this cutoff value. Cox proportional hazards model were used to discover survival outcome-associated factors.
We derived the optimal HALP cutoff as 35.4. A low HALP score (<35.4) predicted poorer overall and disease-free survival (hazard ratio: 2.29 and 1.92, respectively; both p < 0.001) and was significantly associated with OSCC aggressiveness. We established a HALP-based nomogram that accurately predicted overall survival (concordance index: 0.784).
The HALP score may be a useful prognostic biomarker in patients with OSCC undergoing surgery, and the HALP-based nomogram can be a promising prognostic tool in clinical setting.
本研究旨在探讨血红蛋白-白蛋白-淋巴细胞-血小板（HALP）评分在口腔鳞状细胞癌（OSCC）中的预后价值。
回顾性分析了 350 例接受初次手术治疗的 OSCC 患者的临床资料。通过受试者工作特征曲线分析确定最佳 HALP 截断值，并根据该截断值对患者进行分组。采用 Cox 比例风险模型分析与生存结局相关的因素。
我们确定了最佳 HALP 截断值为 35.4。低 HALP 评分（<35.4）预示着总体生存率和无病生存率较差（风险比分别为 2.29 和 1.92，均 p<0.001），且与 OSCC 的侵袭性显著相关。我们建立了一个基于 HALP 的列线图，可以准确预测总体生存率（一致性指数：0.784）。
HALP 评分可能是接受手术治疗的 OSCC 患者的一种有用的预后生物标志物，基于 HALP 的列线图可能是一种有前途的临床预后工具。
