Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Sci Rep. 2024 Jun 5;14(1):12921. doi: 10.1038/s41598-024-63671-y.
We probed the associations of preoperative modified geriatric nutritional risk index (mGNRI) values with prognosis in patients receiving surgery for oral cavity squamous cell carcinoma (OCSCC). This retrospective study analyzed the clinical data of 333 patients with OCSCC and undergoing surgery between 2008 and 2017. The preoperative mGNRI was calculated using the following formula: (14.89/C-reactive protein level) + 41.7 × (actual body weight/ideal body weight). We executed receiver operating characteristic curve analyses to derive the optimal mGNRI cutoff and employed Kaplan-Meier survival curves and Cox proportional hazard model to probe the associations of the mGNRI with overall survival (OS) and disease-free survival (DFS). The optimal mGNRI cutoff was derived to be 73.3. We noted the 5-year OS and DFS rates to be significantly higher in the high-mGNRI group than in the low-mGNRI group (both p < 0.001). A preoperative mGNRI below 73.3 was independently associated with unfavorable DFS and OS. A mGNRI-based nomogram was constructed to provide accurate OS predictions (concordance index, 0.781). Hence, preoperative mGNRI is a valuable and cost-effective prognostic biomarker in patients with OCSCC. Our nomogram facilitates the practical use of mGNRI and offers individualized predictions of OS.
我们探讨了术前改良老年营养风险指数（mGNRI）值与接受口腔鳞状细胞癌（OCSCC）手术患者预后的相关性。本回顾性研究分析了 2008 年至 2017 年间接受手术治疗的 333 例 OCSCC 患者的临床资料。术前 mGNRI 采用以下公式计算：（14.89/C 反应蛋白水平）+41.7×（实际体重/理想体重）。我们执行了接收器操作特征曲线分析以得出最佳 mGNRI 截断值，并采用 Kaplan-Meier 生存曲线和 Cox 比例风险模型探讨 mGNRI 与总生存（OS）和无病生存（DFS）的相关性。得出的最佳 mGNRI 截断值为 73.3。我们注意到高 mGNRI 组的 5 年 OS 和 DFS 率明显高于低 mGNRI 组（均 p<0.001）。术前 mGNRI 低于 73.3 与不利的 DFS 和 OS 独立相关。构建了基于 mGNRI 的列线图以提供准确的 OS 预测（一致性指数，0.781）。因此，术前 mGNRI 是 OCSCC 患者有价值且具有成本效益的预后生物标志物。我们的列线图有助于 mGNRI 的实际应用，并提供 OS 的个体化预测。
