School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Chem Biodivers. 2021 Jul;18(7):e2100033. doi: 10.1002/cbdv.202100033. Epub 2021 Jun 8.
The increasing incidence of metabolic and cardiovascular diseases has severely affected global human health and life safety. In recent years, some effective drugs with remarkable curative effects and few side effects found in natural compounds have attracted attention. Salidroside (SAL), a phenylpropane glycoside, is the main active ingredient of the plateau plant Rhodiola. So far, many animal experiments proved that SAL has good biological activity against some metabolic and cardiovascular diseases. However, most of these reports are scattered. This review systematically summarizes the pharmacological progress of SAL in the treatment of several metabolic (e. g., diabetes and non-alcoholic fatty liver disease) and cardiovascular (e. g., atherosclerosis) diseases in a timely manner to promote the clinical application and basic research of SAL. Accumulating evidence proves that SAL has beneficial effects on these diseases. It can improve glucose tolerance, insulin sensitivity, and β-cell and liver functions, and inhibit adipogenesis, inflammation and oxidative stress. Overall, SAL may be a valuable and potential drug candidate for the treatment of metabolic and cardiovascular diseases. However, more studies especially clinical trials are needed to further confirm its therapeutic effects and molecular mechanisms.
代谢和心血管疾病的发病率不断上升，严重影响了全球人类的健康和生命安全。近年来，从天然化合物中发现的一些具有显著疗效和较少副作用的有效药物引起了人们的关注。红景天苷（SAL）是苯丙素糖苷，是高原植物红景天的主要活性成分。到目前为止，许多动物实验证明 SAL 对一些代谢和心血管疾病具有良好的生物活性。然而，这些报道大多分散在各处。本综述系统地总结了 SAL 在治疗几种代谢性疾病（如糖尿病和非酒精性脂肪肝）和心血管疾病（如动脉粥样硬化）方面的药理学进展，及时促进了 SAL 的临床应用和基础研究。越来越多的证据证明 SAL 对这些疾病有有益的作用。它可以改善葡萄糖耐量、胰岛素敏感性、β细胞和肝脏功能，并抑制脂肪生成、炎症和氧化应激。总的来说，SAL 可能是治疗代谢和心血管疾病的一种有价值和有潜力的药物候选物。然而，还需要更多的研究，特别是临床试验，以进一步证实其治疗效果和分子机制。
