Han Jung Ho, Lee Eun-Ji, Park Wonyoung, Ha Ki-Tae, Chung Hwan-Suck
Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea.
Korean Convergence Medical Science Major, KIOM Campus, University of Science and Technology (UST), Daegu, Republic of Korea.
Front Pharmacol. 2023 Oct 17;14:1275000. doi: 10.3389/fphar.2023.1275000. eCollection 2023.
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.
乳酸脱氢酶（LDH）是一种参与能量代谢的关键酶，存在于全身各种细胞中。其多样的生理功能包括糖酵解，其异常活性与多种疾病相关。靶向LDH已成为药物研发中的一种重要方法，促使人们在天然化合物（如多酚、生物碱和萜类化合物）中鉴定出LDH抑制剂。这些化合物对与LDH相关的疾病具有治疗潜力，包括抗癌作用。然而，必须解决生物利用度有限、溶解度差和潜在毒性等挑战。将天然化合物与LDH抑制剂联合使用在临床前研究中已取得了有前景的结果。本综述强调了天然化合物作为LDH抑制剂用于治疗癌症、心血管疾病和神经退行性疾病的前景。
