Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Physiol Res. 2021 Apr 30;70(2):287-292. doi: 10.33549/physiolres.934629.
Caffeine is well known for reducing fatigue and its effect on behavior is widely studied. Usually, caffeine is not ingested in its pure form but rather in sugar-sweetened beverages such as cola. Our aim was to compare the acute effect of cola and caffeine on locomotor activity. Rats and flies ingested cola or caffeine solution for 24 hours. The open field test revealed higher locomotor activity in cola groups for both flies and rats. Surprisingly, no differences have been observed between caffeineand control group. We conclude that caffeine itself does not explain the effect of cola on locomotor activity. Effect of cola cannot be generalized and interpreted for any caffeinated drink with other contents. Rather, the observed effect on locomotor activity may be caused by interaction of caffeine with other substances present in cola.
咖啡因是众所周知的抗疲劳物质，其对行为的影响也得到了广泛研究。通常情况下，咖啡因并不是以纯物质的形式摄入，而是存在于含糖饮料如可乐中。我们的目的是比较可乐和咖啡因对运动活动的急性影响。大鼠和苍蝇摄入可乐或咖啡因溶液 24 小时。旷场试验表明，可乐组的大鼠和苍蝇的运动活动都更高。令人惊讶的是，咖啡因组与对照组之间没有观察到差异。我们得出结论，咖啡因本身并不能解释可乐对运动活动的影响。可乐的影响不能推广到含有其他成分的任何含咖啡因饮料。相反，观察到的对运动活动的影响可能是由于咖啡因与可乐中存在的其他物质相互作用所致。
