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骨缺损通过诱导膜增强成骨活性得到修复：一例病例报告及文献复习。

Bone defects are repaired by enhanced osteogenic activity of the induced membrane: a case report and literature review.

机构信息

Department of Orthopaedics, Wuxi No. 9 People's Hospital Affiliated to Suzhou University, Liangxi Road No. 999, Wuxi, 214062, Jiangsu, China.

Department of Radiology, Wuxi No. 9 People's Hospital Affiliated to Suzhou University, Liangxi Road No. 999, Wuxi, 214062, Jiangsu, China.

出版信息

BMC Musculoskelet Disord. 2021 May 15;22(1):447. doi: 10.1186/s12891-021-04317-2.

DOI:10.1186/s12891-021-04317-2
PMID:33992104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8126171/
Abstract

BACKGROUND

The induced membrane technique (IMT) is an effective strategy to repair bone defects and involves a two-stage set of surgical procedures. Although the IM has osteogenic activity, bone grafting is necessary in standard IMT. Bone defects repaired completely by osteogenic activity of the IM alone without bone grafts are rare.

CASE PRESENTATION

We present a case of infected fractures and bone defects of the ulna and radius treated with IMT. After the first stage using polymethylmethacrylate (PMMA) beads, X-rays showed that new callus developed after 2 to 4 months, and the defects were repaired completely by 5 months. We also present a literature review on spontaneous osteogenesis of the IM in patients.

CONCLUSIONS

We present a case of infected ulnar and radial bone defects that healed by 5 months after the first stage of the IMT using a PMMA spacer. This finding suggests that local associated inflammatory reactions and bone tissue might enhance the osteogenic activity of the IM, causing spontaneous healing of bone defects. This appears to be the first such case reported in the literature.

摘要

背景

诱导膜技术（IMT）是修复骨缺损的有效策略，涉及两阶段手术。尽管诱导膜具有成骨活性，但在标准 IMT 中需要进行骨移植。单独通过诱导膜的成骨活性完全修复骨缺损的情况很少见。

病例介绍

我们报告了一例采用 IMT 治疗尺骨和桡骨感染性骨折和骨缺损的病例。第一阶段使用聚甲基丙烯酸甲酯（PMMA）珠后，X 射线显示 2 至 4 个月后新骨痂形成，5 个月时完全修复了缺损。我们还对患者的诱导膜自发性成骨进行了文献复习。

结论

我们报告了一例尺骨和桡骨感染性骨缺损的病例，在第一阶段使用 PMMA 间隔器后 5 个月愈合。这一发现表明局部相关炎症反应和骨组织可能增强诱导膜的成骨活性，导致骨缺损的自发愈合。这似乎是文献中首次报道的此类病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/356b1760a505/12891_2021_4317_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/35e99d258e23/12891_2021_4317_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/d4f454c39530/12891_2021_4317_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/f857e4d0867d/12891_2021_4317_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/e2b9bffd1dc3/12891_2021_4317_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/356b1760a505/12891_2021_4317_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/35e99d258e23/12891_2021_4317_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/060abab321a9/12891_2021_4317_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/c855a3062a96/12891_2021_4317_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/d4f454c39530/12891_2021_4317_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f6/8126171/f857e4d0867d/12891_2021_4317_Fig5_HTML.jpg
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