Gong Yiqing, Chen Zhao, Liu Mingjie, Wan Linlin, Wang Chunrong, Peng Huirong, Shi Yuting, Peng Yun, Xia Kun, Qiu Rong, Tang Beisha, Jiang Hong
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
J Clin Neurosci. 2021 Jun;88:39-46. doi: 10.1016/j.jocn.2021.03.004. Epub 2021 Mar 30.
Coronavirus disease 2019 (COVID-19) is currently a global concern, and the psychological impact cannot be overlooked. Our purpose was to evaluate the anxiety and depression in spinocerebellar ataxia (SCA) patients during the pandemic and to analyse the influencing factors. We conducted an online questionnaire survey among 307 SCA patients from China and selected 319 healthy people matched by sex and age as the control group. The questionnaire included general information, the self-rating anxiety scale (SAS), and the self-rating depression scale (SDS). The relevant factors included COVID-19 risk factors, age, sex, body mass index (BMI), educational background, disease course, score on the scale for the assessment and rating of ataxia (SARA), Mini-mental State Examination (MMSE) and International Cooperative Ataxia Rating Scale (ICARS). The proportion of SCA patients with anxiety was 34.9%, and the proportion with depression was 56.7%. The SAS and SDS scores of the SCA patients were significantly higher than those of the control group (SAS: 45.8 ± 10.1 vs. 40.6 ± 8.9, P < 0.01; SDS: 55.1 ± 12.2 vs. 43.6 ± 11.9, P < 0.01). In SCA3, the risk of exposure to COVID-19, educational level, disease course and the severity of ataxia may be factors affecting patients' mental health. More attention should be paid to the mental health of SCA patients during the COVID-19 pandemic.
2019冠状病毒病（COVID-19）目前是全球关注的问题，其心理影响不容忽视。我们的目的是评估疫情期间脊髓小脑共济失调（SCA）患者的焦虑和抑郁情况，并分析影响因素。我们对307名来自中国的SCA患者进行了在线问卷调查，并选取319名年龄和性别匹配的健康人作为对照组。问卷包括一般信息、自评焦虑量表（SAS）和自评抑郁量表（SDS）。相关因素包括COVID-19危险因素、年龄、性别、体重指数（BMI）、教育背景、病程、共济失调评估与评分量表（SARA）得分、简易精神状态检查表（MMSE）和国际合作共济失调评定量表（ICARS）。SCA患者中焦虑的比例为34.9%，抑郁的比例为56.7%。SCA患者的SAS和SDS得分显著高于对照组（SAS：45.8±10.1对40.6±8.9，P<0.01；SDS：55.1±12.2对43.6±11.9，P<0.01）。在SCA3中，接触COVID-19的风险、教育水平、病程和共济失调的严重程度可能是影响患者心理健康的因素。在COVID-19大流行期间，应更加关注SCA患者的心理健康。
