Pharmacy El Toro, La Fuente 11, 12429 El Toro, Castellon, Spain.
Front Neuroendocrinol. 2019 Jul;54:100774. doi: 10.1016/j.yfrne.2019.100774. Epub 2019 Jul 23.
Stress-related psychiatric conditions are one of the main causes of disability in developed countries. They account for a large portion of resource investment in stress-related disorders, become chronic, and remain difficult to treat. Research on the neurobehavioral effects of stress reveals how changes in certain brain areas, mediated by a number of neurochemical messengers, markedly alter behavior. The cerebellum is connected with stress-related brain areas and expresses the machinery required to process stress-related neurochemical mediators. Surprisingly, it is not regarded as a substrate of stress-related behavioral alterations, despite numerous studies that show cerebellar responsivity to stress. Therefore, this review compiles those studies and proposes a hypothesis for cerebellar function in stressful conditions, relating it to stress-induced psychopathologies. It aims to provide a clearer picture of stress-related neural circuitry and stimulate cerebellum-stress research. Consequently, it might contribute to the development of improved treatment strategies for stress-related disorders.
与压力相关的精神疾病是发达国家残疾的主要原因之一。它们在与压力相关的疾病资源投资中占很大一部分，变得慢性化，并且仍然难以治疗。对压力的神经行为影响的研究揭示了特定脑区的变化，这些变化是由许多神经化学信使介导的，显著改变了行为。小脑与与压力相关的大脑区域相连，并表达了处理与压力相关的神经化学介质所需的机制。令人惊讶的是，尽管有许多研究表明小脑对压力有反应，但它并没有被视为与压力相关的行为改变的基质。因此，本综述汇集了这些研究，并提出了一个与压力相关的功能假说，将其与压力引起的精神病理学联系起来。它旨在提供一个更清晰的压力相关神经回路的图片，并刺激小脑压力研究。因此，它可能有助于开发改善与压力相关的疾病的治疗策略。
