Assistant Professor, Department of Oral Diagnostic Sciences, Division of Oral Medicine, King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia.
Assistant Professor, Department of Oral Diagnostic Sciences, Division of Oral Medicine, King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia and Department of Diagnostic Sciences, Division of Oral Medicine, Tufts University School of Dental Medicine, Boston, MA, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Aug;132(2):172-181. doi: 10.1016/j.oooo.2021.03.007. Epub 2021 Mar 18.
The aims of this pilot investigation were to calculate the levels of sensitivity and specificity of salivary glands ultrasonography (SGUS) in diagnosing Sjögren syndrome (SS) and to assess the ultrasonographic findings of parotid and submandibular glands.
Patients diagnosed with SS or dry mouth and healthy controls were enrolled. Bilateral parotid and submandibular glands were assessed for (1) parenchymal inhomogeneity (PIH), (2) median size of the glands, (3) visibility of glandular posterior borders, and (4) size of sialolith, if present.
This study included 34 female patients, of whom 12 had SS (35.3%), 12 had dry mouth (35.3%), and 10 were healthy controls (29.4%). Patients with SS showed higher PIH scores in all glands with the median differences being statistically higher in the right and left parotids and left submandibular glands (P < .001, P = .012, and P < .001, respectively). SGUS, with a PIH cutoff ≥2, showed a sensitivity of 100% and a specificity of 81.6% for detecting SS. The majority of SS had invisible glandular posterior borders (P < .001). Median size of the glands and size of the sialolith did not show any statistically significant differences between groups.
SGUS is a noninvasive imaging modality with good sensitivity and specificity that might be valuable as a diagnostic aid for SS.
本初步研究旨在计算唾液腺超声（SGUS）诊断干燥综合征（SS）的灵敏度和特异度，并评估腮腺和颌下腺的超声表现。
本研究纳入了诊断为 SS 或口干的患者以及健康对照者。双侧腮腺和颌下腺评估（1）实质不均匀性（PIH），（2）腺体的中位大小，（3）腺体后缘的可见性，以及（4）存在涎石时的大小。
本研究共纳入 34 名女性患者，其中 12 名患有 SS（35.3%），12 名患有口干（35.3%），10 名是健康对照者（29.4%）。SS 患者所有腺体的 PIH 评分均较高，右侧和左侧腮腺以及左侧颌下腺的中位差异具有统计学意义（P <.001、P =.012 和 P <.001）。以 PIH≥2 为界的 SGUS 检测 SS 的灵敏度为 100%，特异性为 81.6%。大多数 SS 患者的腺体后缘不可见（P <.001）。各组间腺体中位大小和涎石大小无统计学差异。
SGUS 是一种具有良好灵敏度和特异性的非侵入性成像方式，可能有助于 SS 的诊断。
