Chen Shaoqi, Wang Yukai, Zhang Guohong, Chen Shigao
Department of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Department of Rheumatology, Shantou Central Hospital, Shantou, Guangdong, China.
Biomed Res Int. 2016;2016:2793898. doi: 10.1155/2016/2793898. Epub 2016 Dec 18.
A total of 136 subjects (51 SS patients, 35 sicca syndrome patients without SS, and 50 healthy volunteers) were enrolled in this study. The mean SWV value for salivary glands of SS patients was statistically higher than that of controls (2.81 ± 0.66 m/s versus 1.85 ± 0.28 m/s for parotid glands and 2.29 ± 0.34 m/s versus 1.82 ± 0.25 m/s for submandibular glands, resp.). Combining SWV values of parotid and submandibular glands gives a sensitivity of 88.2% (95% CI: 76.1-95.6%) and specificity of 96.0% (95% CI: 86.3-99.5%) at the cutoff point of 2.19 m/s, with an AUROC of 0.954 (95% CI: 0.893-0.986). In addition, combining SGUS score and SWV value yields a sensitivity of 98.0% (95% CI: 89.6-100%), specificity of 90.0% (95% CI: 78.2-96.7%), and AUROC of 0.962 (95% CI: 0.904-0.990). Classification tree considering the sequential use of SGUS score and SWV value achieved 92.1% accuracy for diagnosis of SS. Similarly, the ROC curve of combined SGUS scores and SWV values yields an AUROC of 0.954 (95% CI: 0.885-0.987), sensitivity of 97.1% (95% CI: 85.1-99.9%), and specificity of 92.2% (95% CI: 81.1-97.8%) for separating sicca syndrome patients (without SS) from SS patients. Combining SGUS and VTQ provides a promising tool for diagnosis of SS.
本研究共纳入136名受试者（51例干燥综合征患者、35例无干燥综合征的口干燥症患者和50名健康志愿者）。干燥综合征患者唾液腺的平均剪切波速度（SWV）值在统计学上高于对照组（腮腺分别为2.81±0.66米/秒和1.85±0.28米/秒，颌下腺分别为2.29±0.34米/秒和1.82±0.25米/秒）。腮腺和颌下腺的SWV值相结合，在截断点为2.19米/秒时，敏感性为88.2%（95%可信区间：76.1 - 95.6%），特异性为96.0%（95%可信区间：86.3 - 99.5%），曲线下面积（AUROC）为0.954（95%可信区间：0.893 - 0.986）。此外，结合唾液腺超声评分（SGUS）和SWV值，敏感性为98.0%（95%可信区间：89.6 - 100%），特异性为90.0%（95%可信区间：78.2 - 96.7%），AUROC为0.962（95%可信区间：0.904 - 0.990）。考虑序贯使用SGUS评分和SWV值的分类树对干燥综合征诊断的准确率达到92.1%。同样，联合SGUS评分和SWV值的ROC曲线得出的AUROC为0.954（95%可信区间：0.885 - 0.987）用于区分无干燥综合征的口干燥症患者和干燥综合征患者时，敏感性为97.1%（95%可信区间：85.1 - 99.9%），特异性为92.2%（95%可信区间：81.1 - 97.8%）。联合SGUS和虚拟触诊组织定量（VTQ）为干燥综合征的诊断提供了一种有前景的工具。
