Corneal and External Eye Disease Service, The Royal Liverpool University Hospital, Liverpool, UK; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria.
Surv Ophthalmol. 2022 Jan-Feb;67(1):31-51. doi: 10.1016/j.survophthal.2021.05.001. Epub 2021 May 13.
The vascular system of the ocular surface plays a central role in infectious, autoimmune, inflammatory, traumatic and neoplastic diseases. The development, application, and monitoring of treatments for vascular abnormalities depends on the in vivo analysis of the ocular surface vasculature. Until recently, ocular surface vascular imaging was confined to biomicroscopic and color photographic assessment, both limited by poor reproducibility and the inability to image lymphatic vasculature in vivo. The evolvement and clinical implementation of innovative imaging modalities including confocal microscopy, intravenous, and optical coherence tomography-based angiography now allows standardized quantitative and functional vascular assessment with potential applicability to automated analysis algorithms and diagnostics.
眼表的脉管系统在感染、自身免疫、炎症、创伤和肿瘤疾病中起着核心作用。血管异常治疗的发展、应用和监测依赖于对眼表脉管系统的活体分析。直到最近，眼表血管成像还局限于生物显微镜和彩色照相评估，这两种方法都受到可重复性差和无法对活体淋巴血管成像的限制。包括共焦显微镜、静脉内和光相干断层扫描血管造影在内的创新成像方式的发展和临床应用，现在可以实现标准化的定量和功能血管评估，并具有应用于自动化分析算法和诊断的潜力。
