Ang Marcus, Tan Anna C S, Cheung Chui Ming Gemmy, Keane Pearse A, Dolz-Marco Rosa, Sng Chelvin C A, Schmetterer Leopold
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Graefes Arch Clin Exp Ophthalmol. 2018 Feb;256(2):237-245. doi: 10.1007/s00417-017-3896-2. Epub 2018 Jan 9.
Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age related macular degeneration and retinal vascular diseases. However, the interpretation of these optical coherence tomography angiography images should be taken in consideration with other multi-modal imaging to overcome the limitations of each technique. In addition, there are a growing variety of clinical applications for optical coherence tomography angiography imaging in optic nerve head evaluation for glaucoma and optic neuropathies. Further developments in anterior optical coherence tomography angiography have now allowed for evaluation of anterior segment pathology such as glaucoma, ocular surface diseases, corneal vascularisation, and abnormal iris vasculature. Future developments in software could allow for improved segmentation and image resolution with automated measurements and analysis.
光学相干断层扫描血管造影是一种非侵入性成像技术，现在能够同时对眼部的形态和血管系统进行体内成像。在本综述中，我们提供了光学相干断层扫描血管造影技术在眼部从前节到后节的现有临床应用的最新情况。我们还讨论了光学相干断层扫描血管造影技术的局限性以及图像解读的注意事项。由于当前的光学相干断层扫描血管造影系统是针对视网膜进行优化的，大多数研究都集中在解读诸如年龄相关性黄斑变性和视网膜血管疾病等病症的图像。然而，这些光学相干断层扫描血管造影图像的解读应结合其他多模态成像来考虑，以克服每种技术的局限性。此外，光学相干断层扫描血管造影成像在青光眼和视神经病变的视神经乳头评估中有着越来越多的临床应用。前节光学相干断层扫描血管造影的进一步发展现在已经能够评估前节病变，如青光眼、眼表疾病、角膜血管化和虹膜血管异常。软件的未来发展可能会通过自动测量和分析实现更好的分割和图像分辨率。
