Department of Gastroenterology, The Affiliated People's Hospital of Ningbo University, Zhejiang, China.
Department of Infectious Disease, Beilun People's Hospital, Ningbo, China.
Cancer Epidemiol. 2021 Aug;73:101949. doi: 10.1016/j.canep.2021.101949. Epub 2021 May 13.
Biliary tract cancer (BTC) is a rare malignant neoplasm with poor prognosis. We aimed to report the rates and the trends of biliary tract cancer at the global level from 1990 to 2017 according to gender, age and social-demographic index (SDI).
Data on biliary tract cancer between 1990 and 2017 was acquired from the 2017 Global Burden of Disease (GBD) study including the incidence, death and disability adjusted life-years (DALY). We also calculated estimated annual percentage changes (EAPC) to quantificationally describe the trend of incidence, death and DALY over time.
Overall, the number of biliary tract cancer increased from 119,943 in 1990 to 210,878 in 2017. The age-standardized incidence rate (ASIR) decreased continuously in this period with an EAPC of -0.56 (-0.67 to -0.45). The age-standardized death rate (ASDR) declined from 2.79 (95 % CI 2.68 - 3.14) in 1990 to 2.23 (95 % CI 1.99 - 2.38) per 100,000 persons in 2017. In terms of SDI, ASIR and ASDR were increased in low- and low-middle- SDI regions, but decreased in the other three regions, so was the age-standardized DALY rate. The ASR (Age-standardized incidence/mortality/DALY rate) varied across the world, with the highest ASIR and ASDR in Chile, and the lowest ones in Iraq.
The ASIR, ASDR and age-standardized DALY rate of biliary tract cancer have decreased at the global level. However, changes in rates vary among different counties and regions, suggesting it is more reasonable to adopt targeted and specific measures to decrease the occurrence of cancer.
胆道癌（BTC）是一种预后不良的罕见恶性肿瘤。我们旨在根据性别、年龄和社会人口指数（SDI）报告 1990 年至 2017 年全球胆道癌的发病率和趋势。
1990 年至 2017 年胆道癌的数据来自 2017 年全球疾病负担（GBD）研究，包括发病率、死亡率和残疾调整生命年（DALY）。我们还计算了估计的年变化百分比（EAPC），以定量描述发病率、死亡率和 DALY 随时间的变化趋势。
总体而言，1990 年胆道癌的发病人数为 119943 人，2017 年增加到 210878 人。在此期间，年龄标准化发病率（ASIR）持续下降，EAPC 为-0.56（-0.67 至-0.45）。年龄标准化死亡率（ASDR）从 1990 年的每 10 万人 2.79（95%CI 2.68-3.14）下降到 2017 年的每 10 万人 2.23（95%CI 1.99-2.38）。就 SDI 而言，低和中低 SDI 地区的 ASIR 和 ASDR 增加，而其他三个地区则下降，年龄标准化 DALY 率也是如此。全球范围内的 ASR（年龄标准化发病率/死亡率/ DALY 率）存在差异，智利的 ASIR 和 ASDR 最高，伊拉克的最低。
全球胆道癌的 ASIR、ASDR 和年龄标准化 DALY 率均有所下降。然而，不同国家和地区的发病率变化不同，这表明采取有针对性和具体的措施来降低癌症的发生更为合理。
