Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Department of Stomatology & Center for Evidence-Based Medicine and Clinical Research, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Respirology. 2023 Jan;28(1):29-36. doi: 10.1111/resp.14349. Epub 2022 Aug 23.
Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease. This study investigated the global, regional and country burden of COPD based on gender, age and socio-demographic indices (SDIs) in the last 30-year period from 1990 to 2019.
The COPD data, including incidence, mortality and disability-adjusted life years (DALYs), were obtained from the 2019 Global Burden of Disease Study. If age-standardized incidence rate (ASIR) or death rate (ASDR) remains almost constant or decreases, the number of cases will still increase as the global population increases substantially. Estimated annual percentage change (EAPC) was calculated to assess incidence, mortality and DALY trends.
The incidence of COPD increased by 85.89% from 8,722,966 cases in 1990 to 16,214,828 cases in 2019, and the ASIR decreased from 216.48/100,000 persons in 1990 (95%UI, 204.56-227.33) to 200.49 per 100,000 persons (95%UI, 188.63-212.57) in 2019. The ASIR increased (EAPC = 0.05, 95%CI, 0.01-0.10) in the low SDI region, was stable in the high SDI region, and fell in the other three SDI regions. Men had a higher ASIR than women over the past 30 years, and there were differences in the incidence rates for different age groups. Male mortality and DALYs were higher than female mortality. ASDR decreased by 2.13% (95%CI, -2.23% to -2.02%) per year and the annual age-standardized DALY rate decreased by 1.97% (95%CI, -2.05% to -1.89%).
The ASIR, ASDR and age-standardized DALY rate of COPD declined overall in the last 30 years, and were highest in the low-middle SDI region.
慢性阻塞性肺疾病（COPD）是最常见的慢性呼吸道疾病。本研究基于性别、年龄和社会人口学指数（SDI），调查了 1990 年至 2019 年过去 30 年期间全球、区域和国家 COPD 的负担。
COPD 数据包括发病率、死亡率和伤残调整生命年（DALY），来自 2019 年全球疾病负担研究。如果年龄标准化发病率（ASIR）或死亡率（ASDR）保持几乎不变或下降，由于全球人口大幅增加，病例数量仍将增加。计算估计年变化百分比（EAPC）以评估发病率、死亡率和 DALY 的趋势。
1990 年 COPD 发病率为 8722966 例，2019 年增至 16214828 例，增加 85.89%；1990 年 ASIR 为 216.48/100000 人（95%UI，204.56-227.33），2019 年降至 200.49/100000 人（95%UI，188.63-212.57）。低 SDI 地区 ASIR 增加（EAPC=0.05，95%CI，0.01-0.10），高 SDI 地区保持稳定，其他三个 SDI 地区下降。过去 30 年，男性 ASIR 高于女性，不同年龄组发病率不同。男性死亡率和 DALY 高于女性。ASDR 每年下降 2.13%（95%CI，-2.23%至-2.02%），年龄标准化 DALY 率每年下降 1.97%（95%CI，-2.05%至-1.89%）。
过去 30 年，COPD 的 ASIR、ASDR 和年龄标准化 DALY 率总体呈下降趋势，中低 SDI 地区最高。
