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HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19.人内源性逆转录病毒-W包膜蛋白在血液白细胞中的表达作为新型冠状病毒肺炎疾病严重程度的标志物
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Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients.在与 COVID-19 患者的呼吸道转归相关的 T 淋巴细胞中发现致病性 HERV-W 包膜表达的证据。
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Human endogenous retrovirus envelope proteins target dendritic cells to suppress T-cell activation.人类内源性逆转录病毒包膜蛋白靶向树突状细胞以抑制 T 细胞激活。
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HBV X Protein induces overexpression of HERV-W env through NF-κB in HepG2 cells.乙肝病毒X蛋白通过核因子κB诱导人肝癌细胞系HepG2中内源性逆转录病毒-W包膜蛋白的过表达。
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Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope.人类内源性逆转录病毒HERV-W的包膜基因编码一种功能性逆转录病毒包膜。
J Virol. 2001 Apr;75(7):3488-9. doi: 10.1128/JVI.75.7.3488-3489.2001.
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The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus.人类内源性逆转录病毒HERV-W的包膜糖蛋白可诱导细胞对脾坏死病毒产生抗性。
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HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells.人类内源性逆转录病毒 W 的 env 蛋白通过与 DISC1 共同作用抑制来激活 TRPC3 通道调节钙离子内流。
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Human endogenous retrovirus W family envelope gene activates the small conductance Ca2+-activated K+ channel in human neuroblastoma cells through CREB.人类内源性逆转录病毒 W 家族包膜基因通过 CREB 激活人神经母细胞瘤细胞中的小电导钙激活钾通道。
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Expression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta.人早孕胎盘绒毛外滋养层中内源性逆转录病毒-W包膜糖蛋白（合胞素）的表达
Placenta. 2005 Aug;26(7):556-62. doi: 10.1016/j.placenta.2004.09.002.

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The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus.SARS-CoV-2 感染与 1 型糖尿病之间的关系。
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Front Immunol. 2024 Apr 5;15:1294020. doi: 10.3389/fimmu.2024.1294020. eCollection 2024.
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p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics).SARS-CoV-2感染中的p53/NF-κB平衡：从组学、基因组学和药物基因组学见解到定制治疗前景（新冠组学）
Front Pharmacol. 2022 May 27;13:871583. doi: 10.3389/fphar.2022.871583. eCollection 2022.
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Virus-Induced Membrane Fusion in Neurodegenerative Disorders.病毒诱导的神经退行性疾病中的膜融合。
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Syncytin, envelope protein of human endogenous retrovirus (HERV): no longer 'fossil' in human genome.人内源性逆转录病毒（HERV）的包膜蛋白——合胞素：在人类基因组中不再是“化石”。
Anim Cells Syst (Seoul). 2022 Jan 12;25(6):358-368. doi: 10.1080/19768354.2021.2019109. eCollection 2021.
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Human Endogenous Retroviruses as Gene Expression Regulators: Insights from Animal Models into Human Diseases.人类内源性逆转录病毒作为基因表达调控因子：来自动物模型的人类疾病研究进展。
Mol Cells. 2021 Dec 31;44(12):861-878. doi: 10.14348/molcells.2021.5016.
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SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements.SARS-CoV-2 感染介导人类内源性逆转录病毒和长散布核元件的差异表达。
JCI Insight. 2021 Dec 22;6(24):e147170. doi: 10.1172/jci.insight.147170.

本文引用的文献

1
Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients.在与 COVID-19 患者的呼吸道转归相关的 T 淋巴细胞中发现致病性 HERV-W 包膜表达的证据。
EBioMedicine. 2021 Apr;66:103341. doi: 10.1016/j.ebiom.2021.103341. Epub 2021 Apr 15.
2
Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review.替利珠单抗，一种 IgG4 抗人类内源性逆转录病毒单克隆抗体：早期开发安全性综述。
Drug Saf. 2020 Dec;43(12):1287-1296. doi: 10.1007/s40264-020-00988-3.
3
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications.深度免疫剖析 COVID-19 患者，揭示具有治疗意义的不同免疫类型。
Science. 2020 Sep 4;369(6508). doi: 10.1126/science.abc8511. Epub 2020 Jul 15.
4
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.COVID-19 疾病患者和未接触者体内针对 SARS-CoV-2 冠状病毒的 T 细胞反应的靶标。
Cell. 2020 Jun 25;181(7):1489-1501.e15. doi: 10.1016/j.cell.2020.05.015. Epub 2020 May 20.
5
Syncytin-1/HERV-W envelope is an early activation marker of leukocytes and is upregulated in multiple sclerosis patients.Syncytin-1/HERV-W 包膜是白细胞的早期激活标志物，在多发性硬化症患者中上调。
Eur J Immunol. 2020 May;50(5):685-694. doi: 10.1002/eji.201948423. Epub 2020 Feb 11.
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Human Endogenous Retroviruses in Neurological Diseases.人类内源性逆转录病毒与神经系统疾病
Trends Mol Med. 2018 Apr;24(4):379-394. doi: 10.1016/j.molmed.2018.02.007. Epub 2018 Mar 15.
7
Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis.人类内源性逆转录病毒-W 在血细胞和星形细胞中被 Epstein Barr 病毒表达和激活：多发性硬化症的推论。
PLoS One. 2012;7(9):e44991. doi: 10.1371/journal.pone.0044991. Epub 2012 Sep 27.
8
Molecular characterization of the HERV-W env gene in humans and primates: expression, FISH, phylogeny, and evolution.人类和灵长类动物中HERV-W env基因的分子特征：表达、荧光原位杂交、系统发育及进化
Mol Cells. 2008 Jul 31;26(1):53-60. Epub 2008 Jun 4.
9
Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family.人类内源性逆转录病毒HERV-W家族的染色体分布及编码能力
AIDS Res Hum Retroviruses. 2000 May 20;16(8):731-40. doi: 10.1089/088922200308738.
10
An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.人类内源性逆转录病毒HERV-W的一种包膜糖蛋白在人胎盘中表达，并使表达D型哺乳动物逆转录病毒受体的细胞发生融合。
J Virol. 2000 Apr;74(7):3321-9. doi: 10.1128/jvi.74.7.3321-3329.2000.

HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19.

作者信息

Garcia-Montojo Marta, Nath Avindra

机构信息

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

出版信息

EBioMedicine. 2021 May;67:103363. doi: 10.1016/j.ebiom.2021.103363. Epub 2021 May 13.

DOI:10.1016/j.ebiom.2021.103363
PMID:33993053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8116818/
Abstract
摘要