An D S, Chen I S
Department of Microbiology, Immunology, Molecular Genetics, and Medicine, UCLA AIDS Institute, University of California-Los Angeles, Los Angeles, California 90095, USA.
J Virol. 2001 Apr;75(7):3488-9. doi: 10.1128/JVI.75.7.3488-3489.2001.
A member of the human endogenous retrovirus (HERV) family termed HERV-W encodes a highly fusogenic membrane glycoprotein that appears to be expressed specifically in the placenta. It is unclear whether the glycoproteins of the HERVs can serve as functional retrovirus envelope proteins to confer infectivity on retrovirus particles. We found that the HERV-W envelope glycoprotein can form pseudotypes with human immunodeficiency virus type 1 virions and confers tropism for CD4-negative cells. Thus, the HERV-W env gene represents the first HERV env gene demonstrated to encode the functional properties of a retrovirus envelope glycoprotein.
人类内源性逆转录病毒（HERV）家族中的一个成员，即HERV-W，编码一种高度融合的膜糖蛋白，该蛋白似乎在胎盘中特异性表达。目前尚不清楚HERV的糖蛋白是否可以作为功能性逆转录病毒包膜蛋白，赋予逆转录病毒颗粒感染性。我们发现，HERV-W包膜糖蛋白可以与人免疫缺陷病毒1型病毒粒子形成假型，并赋予对CD4阴性细胞的嗜性。因此，HERV-W env基因是首个被证明编码逆转录病毒包膜糖蛋白功能特性的HERV env基因。
