组蛋白尾部和 DNA 被表观遗传阅读器识别的机制相似性。
Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.
机构信息
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
出版信息
Curr Opin Struct Biol. 2021 Dec;71:1-6. doi: 10.1016/j.sbi.2021.04.003. Epub 2021 May 13.
Abstract
The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to interact with the nucleosome through concomitant binding to histones and DNA has emerged. In this review, we discuss mechanistic insights underlying bivalent histone and DNA recognition by newly characterized readers and highlight the importance of binding to DNA for their association with chromatin.
摘要
过去二十年见证了在鉴定和描述能够识别组蛋白翻译后修饰的表观遗传读取子方面的快速进展。最近，出现了一组新的读取子，它们能够通过与组蛋白和 DNA 的同时结合与核小体相互作用。在这篇综述中，我们讨论了新鉴定的读取子对二价组蛋白和 DNA 识别的机制见解，并强调了与 DNA 结合对于它们与染色质结合的重要性。
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