吸入沙丁胺醇的代谢效应。
The metabolic effects of inhaled salbutamol.
作者信息
Bateman S M, Pidgeon J, Spiro S G, Johnson A J
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):127-9. doi: 10.1111/j.1365-2125.1978.tb01612.x.
Abstract
1 The metabolic effects of salbutamol (5 mg) given by intermittent positive pressure breathing have been studied in eight patients with airflow obstruction. 2 No changes in plasma nonesterified fatty acids, triglyceride, glucose, insulin or cortisol were seen 1 and 4 h after administration. 3 It is concluded that inhaled salbutamol does not cause the unwanted metabolic effects reported with oral or parenteral administration, and that this is a further indication for this route of administration.
摘要
- 对8例气流阻塞患者进行了间歇正压通气给予沙丁胺醇（5毫克）的代谢效应研究。2. 给药后1小时和4小时，血浆非酯化脂肪酸、甘油三酯、葡萄糖、胰岛素或皮质醇均无变化。3. 得出结论：吸入沙丁胺醇不会引起口服或胃肠外给药所报告的不良代谢效应，这是该给药途径的又一依据。
相似文献
1
The metabolic effects of inhaled salbutamol.吸入沙丁胺醇的代谢效应。
Br J Clin Pharmacol. 1978 Feb;5(2):127-9. doi: 10.1111/j.1365-2125.1978.tb01612.x.
2
Metabolic effects of oral salbutamol in late pregnancy.口服沙丁胺醇对妊娠晚期的代谢影响。
Eur J Clin Pharmacol. 1978 Nov 16;14(2):95-9. doi: 10.1007/BF00607438.
3
Metabolic effects of oral salbutamol.口服沙丁胺醇的代谢效应。
Br Med J. 1976 Jan 3;1(6000):22. doi: 10.1136/bmj.1.6000.22.
4
Airway and metabolic resistance to intravenous salbutamol: a study in normal man.气道及对静脉注射沙丁胺醇的代谢性抵抗：一项在正常男性中的研究。
Clin Sci (Lond). 1980 Sep;59(3):155-61. doi: 10.1042/cs0590155.
5
[Metabolic effects of salbutamol].[沙丁胺醇的代谢作用]
Bronches. 1975 May-Jun;25(3):166-76.
6
Some metabolic and hormonal effects of salbutamol in man.
Acta Diabetol Lat. 1976 May-Aug;13(3-4):146-53. doi: 10.1007/BF02581259.
7
Metabolic effects of salbutamol: comparison of aerosol and intravenous administration.沙丁胺醇的代谢效应：气雾剂与静脉给药的比较
Br Med J. 1977 Feb 12;1(6058):413-4. doi: 10.1136/bmj.1.6058.413.
8
Metabolic and cardiovascular effects of salbutamol in atopic subjects with and without asthma.沙丁胺醇对有和无哮喘的特应性受试者的代谢和心血管影响。
Scand J Respir Dis. 1979 Feb;60(1):44-8.
9
The effects of salbutamol on some metabolic and endocrine patterns of diabetic subjects.沙丁胺醇对糖尿病患者某些代谢和内分泌模式的影响。
Pharmacol Res Commun. 1980 Oct;12(9):909-19. doi: 10.1016/s0031-6989(80)80055-5.
10
Metabolic response to intravenous salbutamol therapy in acute asthma.急性哮喘患者静脉注射沙丁胺醇治疗后的代谢反应
Thorax. 1977 Apr;32(2):182-4. doi: 10.1136/thx.32.2.182.
引用本文的文献
1
Cardiovascular and biochemical responses to nebulised salbutamol in normal subjects.正常受试者对雾化沙丁胺醇的心血管和生化反应。
Br J Clin Pharmacol. 1984 Oct;18(4):641-4. doi: 10.1111/j.1365-2125.1984.tb02520.x.
2
Adrenergic drugs.肾上腺素能药物。
Clin Rev Allergy. 1983 Mar;1(1):87-104. doi: 10.1007/BF02991319.
3
Assessment of work performance in asthma for determination of cardiorespiratory fitness and training capacity.评估哮喘患者的工作表现以确定心肺适能和训练能力。
Thorax. 1988 Oct;43(10):745-9. doi: 10.1136/thx.43.10.745.
4
Adverse reactions to beta 2-agonist bronchodilators.β2 受体激动剂支气管扩张剂的不良反应。
Med Toxicol. 1986 Jul-Aug;1(4):286-99. doi: 10.1007/BF03259844.
本文引用的文献
1
The fluorometric assay of triglyceride by a semiautomated method.甘油三酯的半自动化荧光测定法。
Anal Biochem. 1968 Oct 24;25(1):246-51. doi: 10.1016/0003-2697(68)90097-3.
2
Free fatty acid estimation by a semi-automated fluorimetric method.
Clin Chim Acta. 1973 Dec 27;49(3):341-8. doi: 10.1016/0009-8981(73)90231-3.
3
Metabolic response during impending myocardial infarction. II. Clinical implications.
Circulation. 1972 Feb;45(2):491-500. doi: 10.1161/01.cir.45.2.491.
4
Metabolic responses to selective beta-adrenergic stimulation in man.人体对选择性β-肾上腺素能刺激的代谢反应。
Postgrad Med J. 1975 Feb;51(592):53-8. doi: 10.1136/pgmj.51.592.53.
5
Comparison of two methods of administering bronchodilator aerosol to asthmatic patients.两种向哮喘患者施用支气管扩张气雾剂方法的比较。
Br Med J. 1975 Apr 19;2(5963):119-20. doi: 10.1136/bmj.2.5963.119.
6
Metabolic response to intravenous salbutamol therapy in acute asthma.急性哮喘患者静脉注射沙丁胺醇治疗后的代谢反应
Thorax. 1977 Apr;32(2):182-4. doi: 10.1136/thx.32.2.182.
7
Metabolic effects of oral salbutamol.口服沙丁胺醇的代谢效应。
Br Med J. 1976 Jan 3;1(6000):22. doi: 10.1136/bmj.1.6000.22.
Zotero 插件