正常受试者对雾化沙丁胺醇的心血管和生化反应。
Cardiovascular and biochemical responses to nebulised salbutamol in normal subjects.
作者信息
Smith S R, Ryder C, Kendall M J, Holder R
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):641-4. doi: 10.1111/j.1365-2125.1984.tb02520.x.
Abstract
When conventional therapeutic doses of nebulised salbutamol were given to normal volunteers, there was a significant rise in pulse rate, systolic blood pressure and plasma glucose and a significant fall in diastolic blood pressure and serum potassium in comparison with placebo. Such changes may be potentially hazardous in certain situations. Patients with airways obstruction due to chronic bronchitis who have coexistent ischaemic heart disease or diuretic induced hypokalaemia may be at particular risk from the unwanted cardiovascular and biochemical responses to nebulised salbutamol.
摘要
当给正常志愿者雾化吸入常规治疗剂量的沙丁胺醇时，与使用安慰剂相比，脉搏率、收缩压和血糖显著升高，舒张压和血清钾显著降低。在某些情况下，这些变化可能具有潜在危险性。患有慢性支气管炎导致气道阻塞且并存缺血性心脏病或利尿剂诱发低钾血症的患者，可能因雾化吸入沙丁胺醇产生的不良心血管和生化反应而面临特别风险。
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本文引用的文献
1
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Am J Med. 1981 Apr;70(4):762-8. doi: 10.1016/0002-9343(81)90530-1.
2
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J Clin Hosp Pharm. 1982 Mar;7(1):31-6. doi: 10.1111/j.1365-2710.1982.tb00905.x.
3
Comparison of inhaled and intravenous terbutaline in acute severe asthma.吸入性与静脉注射特布他林治疗急性重度哮喘的比较。
Thorax. 1981 Aug;36(8):629-31. doi: 10.1136/thx.36.8.629.
4
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5
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6
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