Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Centre for Interventional Paediatric Psychopharmacology and Rare Diseases (CIPPRD), National and Specialist Child and Adolescent Mental Health Services, Maudsley Hospital, London, UK.
J Autism Dev Disord. 2022 Apr;52(4):1568-1586. doi: 10.1007/s10803-021-05046-0. Epub 2021 May 15.
Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.
精神病性体验可发生于自闭症谱系障碍（ASD）中。一些有这些体验的 ASD 个体可能符合精神病高危（CHR-P）标准。对 ASD 和 CHR-P 的相关文献进行了系统检索，并对 CHR-P 在 ASD 中的比例进行了荟萃分析。系统综述纳入了 13 项研究。纳入研究中 ASD 个体的平均年龄为 11.09 岁。最常报告的是精神病前驱期综合征亚组。对 4 项研究进行了荟萃分析，结果显示 11.6%的 CHR-P 个体被诊断为 ASD。前驱期精神病症状可能存在于 ASD 个体中。从 CHR-P 到精神病的转变不受 ASD 的影响。
