Suppr超能文献

单次口服加巴喷丁对犬类暴风雨恐惧症的影响:一项双盲、安慰剂对照交叉试验。

Effects of a single oral dose of gabapentin on storm phobia in dogs: A double-blind, placebo-controlled crossover trial.

作者信息

Bleuer-Elsner Stephane, Medam Tiphaine, Masson Sylvia

机构信息

University of Haifa and Private Practice, Tel Aviv, Israel.

PhD Cognitive Psychology, Jouques, France.

出版信息

Vet Rec. 2021 Oct;189(7):e453. doi: 10.1002/vetr.453. Epub 2021 May 16.

Abstract

BACKGROUND

Storm phobia in companion dogs is a common disorder that significantly impacts dogs' welfare. Gabapentin, the action of which is only partially understood, is widely used for its antiepileptic and analgesic properties. Only recently, the veterinary community began to use gabapentin to address phobia and anxiety in dogs. This study tested gabapentin to lower fear responses of dogs during a thunderstorm event.

METHODS

Eighteen dogs suffering from storm phobia completed our double-blind, placebo-controlled crossover trial. Each dog's behaviour was evaluated twice by his owner: once under placebo, once under gabapentin. The treatment was orally administered at least 90 min before the exposure. Gabapentin was given at a dose ranging from 25 to 30 mg/kg.

RESULTS

Our results indicate a significant reduction of the fear responses of dogs under gabapentin. The adverse effects were rare, and the most frequent amongst them was ataxia.

CONCLUSION

In this trial, gabapentin appears to be an efficient and safe molecule that should be considered as part of the treatment plan of storm phobia in dogs.

摘要

背景

伴侣犬的暴风雨恐惧症是一种常见疾病,会严重影响犬类的健康。加巴喷丁的作用仅部分为人所知,因其抗癫痫和镇痛特性而被广泛使用。直到最近,兽医界才开始使用加巴喷丁来解决犬类的恐惧症和焦虑问题。本研究测试了加巴喷丁在雷暴事件期间降低犬类恐惧反应的效果。

方法

18只患有暴风雨恐惧症的犬完成了我们的双盲、安慰剂对照交叉试验。每只犬的行为由其主人评估两次:一次在服用安慰剂时,一次在服用加巴喷丁时。治疗在暴露前至少90分钟口服给药。加巴喷丁的给药剂量为25至30毫克/千克。

结果

我们的结果表明,服用加巴喷丁的犬的恐惧反应显著降低。不良反应很少见,其中最常见的是共济失调。

结论

在本试验中,加巴喷丁似乎是一种有效且安全的药物,应被视为犬类暴风雨恐惧症治疗方案的一部分。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验