Pneumology Department, Research Laboratory RL18SP02, University of Tunis El Manar, La Rabta Hospital, Tunis, Tunisia.
Am J Mens Health. 2021 May-Jun;15(3):15579883211015857. doi: 10.1177/15579883211015857.
Maximal voluntary inspiratory breath-holding time (MVIBHT) has proved to be of clinical utility in some obstructive ventilatory defects. This study aims to correlate the breath-holding time with pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD) and to determine the feasibility of using a breath-holding test in assessing the severity of COPD.A cross-sectional study including male patients with stable COPD were conducted. Patients with respiratory comorbidities and severe or unstable cardiac diseases were excluded. Patients were interviewed and examined. Six-minute walk test (6MWT) and plethysmography were performed.For MVIBHT collection, the subject was asked to inspire deeply and to hold the breath as long as possible at the maximum inspiratory level. This maneuver was repeated three times. The best value was used for further analysis.A total of 79 patients (mean age: 64.2 ± 8) were included in this study. The mean value of MVIBHT was 24.2 ± 8.5 s. We identified a positive and significant correlations between MVIBHT and forced vital capacity ( = .630; < .001) as well as MVIBHT and forced expiratory volume in 1 s (FEV1%) ( = .671; < .001). A significant inverse correlation with total lung capacity ( = -.328; = .019) and residual volume to total lung capacity ratio ( = -.607; < .001) was noted. MVIBHT was significantly correlated to the distance in the 6MWT ( = .494; < .001). The mean MVIBHT was significantly different within spirometric grades ( < .001) and GOLD groups ( = .002). At 20.5 s, MVIBHT had a sensitivity of 72% and specificity of 96% in determining COPD patients with FEV1 <50%.Our results provide additional evidence of the usefulness of MVIBHT in COPD patients as a pulmonary function parameter.
最大自主吸气保持时间（MVIBHT）已被证明在某些阻塞性通气缺陷中具有临床应用价值。本研究旨在探讨慢性阻塞性肺疾病（COPD）患者的呼吸暂停时间与肺功能测试的相关性，并确定呼吸暂停测试在评估 COPD 严重程度中的可行性。
进行了一项包括稳定期 COPD 男性患者的横断面研究。排除了有呼吸合并症和严重或不稳定型心脏病的患者。对患者进行了访谈和检查。进行了 6 分钟步行测试（6MWT）和体描法。
为了收集 MVIBHT，要求患者深吸气并尽可能在最大吸气水平屏住呼吸。该动作重复三次，取最佳值进行进一步分析。
本研究共纳入 79 例患者（平均年龄：64.2±8 岁）。MVIBHT 的平均时间为 24.2±8.5s。我们发现 MVIBHT 与用力肺活量（r=0.630；P<0.001）以及 1 秒用力呼气量（FEV1%）（r=0.671；P<0.001）呈正显著相关。MVIBHT 与总肺容量（r=-0.328；P=0.019）和残气量/总肺容量比值（r=-0.607；P<0.001）呈显著负相关。MVIBHT 与 6MWT 中的距离呈显著相关（r=0.494；P<0.001）。MVIBHT 在肺功能分级（P<0.001）和 GOLD 组（P=0.002）中差异显著。MVIBHT 在预测 FEV1<50%的 COPD 患者时，其截断值为 20.5s，具有 72%的敏感性和 96%的特异性。
我们的研究结果进一步证实了 MVIBHT 在 COPD 患者中作为肺功能参数的有用性。
