Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, University of Brasília, Distrito Federal, Brazil.
Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, University of Brasília, Brasília, Brazil.
J Equine Vet Sci. 2021 Jun;101:103426. doi: 10.1016/j.jevs.2021.103426. Epub 2021 Feb 28.
Skin lesions are among the leading diseases in equids, and the urogenital region is considered the third most frequently affected body location with tumors and tumor-like skin lesions in horses. Tumor-like skin lesions or multiple tumors of different types in the equine prepuce and penis are a challenging clinical presentation leading to misdiagnosis and subsequent ineffective treatment. An 18-year-old 395-kg male mixed-breed gelding was referred for evaluation of preputial enlargement. Clinical examination revealed a 2.5 × 2.0 × 0.8 cm proliferative ulcerated lesion on the penile mucosa, five ulcerated and circumscribed hardened wounds on the preputial skin fold from 2.0 to 6.0 cm in diameter, and multiple variable-sized raised exophytic lesions ranging from 2.0 mm to 2.3 cm cauliflower-like lesions throughout the prepuce and penis. Pathological and immunohistochemical findings confirmed the definitive diagnosis of three distinct proliferative lesions: squamous cell carcinoma, squamous viral papilloma and cutaneous habronemiasis. Additionally, we present features of concurrent habronemiasis and squamous cell carcinoma and highlight the importance of proper diagnostic approach in the prognosis and correct treatment selection.
皮肤损伤是马属动物的主要疾病之一，而泌尿生殖区被认为是第三大常受影响的身体部位，在马中会出现肿瘤和肿瘤样皮肤损伤。在马的包皮和阴茎中出现肿瘤样皮肤损伤或多种不同类型的肿瘤是一种具有挑战性的临床表现，可能导致误诊和随后的无效治疗。我们收治了一例 18 岁、395 公斤重的雄性杂种骟马，因包皮肿大而就诊。临床检查发现阴茎黏膜上有一个 2.5×2.0×0.8 厘米的增生性溃疡性病变，包皮褶皱处有五个溃疡性和界限分明的硬结伤口，直径从 2.0 厘米到 6.0 厘米不等，包皮和阴茎上还有多个大小不一的外生性隆起病变，从 2.0 毫米到 2.3 厘米呈菜花状病变。组织病理学和免疫组织化学检查结果证实了三个不同的增生性病变的明确诊断：鳞状细胞癌、鳞状病毒性乳头状瘤和皮肤嗜皮蝇蛆病。此外，我们还介绍了同时患有嗜皮蝇蛆病和鳞状细胞癌的特征，并强调了正确诊断方法对预后和正确治疗选择的重要性。
