Delpech B, Delpech A, Vidard M N, Girard N, Tayot J, Clement J C, Creissard P
Br J Cancer. 1978 Jan;37(1):33-40. doi: 10.1038/bjc.1978.5.
Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.
在神经肿瘤提取物中检测了胶质纤维酸性蛋白(GFA),并通过间接免疫荧光研究在这些肿瘤中定位。我们得出结论,GFA是恶性和正常星形胶质细胞的特异性标志物。非星形细胞肿瘤(少突胶质细胞瘤、脑膜瘤)不含GFA。具有星形细胞分化潜能的肿瘤(髓母细胞瘤)可能含有GFA。显微镜检查和GFA检测结果的比较使我们得出结论,GFA浓度与肿瘤中恶性星形胶质细胞的数量成正比,与肿瘤的坏死面积成反比。发现正常组织GFA和胶质母细胞瘤GFA在免疫上是相同的。