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胰腺导管内腺癌转移:文献首例报道。

Intramedullary pancreatic adenocarcinoma metastasis: The first case in literature.

作者信息

Tahta Alican, Cetinkal Ahmet, Calis Elif, Dinc Cem

机构信息

Istanbul Medipol University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Istanbul Medipol University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.

出版信息

Neurocirugia (Engl Ed). 2021 May 13. doi: 10.1016/j.neucir.2021.03.005.

Abstract

BACKGROUND

Pancreatic cancer is a common gastrointestinal malignancy, and is often associated with a poor prognosis. Although liver is generally seen as a distant metastasis point, it has been shown that it can metastasize to any organ, especially the gastrointestinal tract, and approximately 0.3% of metastases are observed in spinal cord.

CASE DESCRIPTION

We report a 36-year-old woman with a prior history of pancreatic adenocarcinoma who presented to us with a thoracic intramedullary lesion and recent onset of neurological deficits. She underwent surgery with histological confirmation of a diagnosis of metastatic adenocarcinoma.

CONCLUSION

To our knowledge there is no prior report of pure intramedullary spinal cord metastasis from a pancreatic adenocarcinoma in the literature. We report the present patient in view of the rarity of intramedullary spinal cord metastasis and its clinical significance. Although intramedullary metastases are rare, they should be investigated in every patient with malignancy and progressive neurological deficit. While its general prognosis is poor regardless of the type of treatment, early diagnosis and treatment is important in terms of quality of life and survival.

摘要

背景

胰腺癌是一种常见的胃肠道恶性肿瘤,预后通常较差。尽管肝脏一般被视为远处转移部位,但研究表明胰腺癌可转移至任何器官,尤其是胃肠道,约0.3%的转移发生在脊髓。

病例描述

我们报告一名36岁女性,既往有胰腺腺癌病史,因出现胸段髓内病变及近期神经功能缺损前来就诊。她接受了手术,术后组织学检查确诊为转移性腺癌。

结论

据我们所知,文献中此前尚无胰腺腺癌单纯脊髓髓内转移的报道。鉴于脊髓髓内转移罕见及其临床意义,我们报告了本病例。尽管髓内转移罕见,但对于每一位患有恶性肿瘤且出现进行性神经功能缺损的患者都应进行检查。无论采用何种治疗方式,其总体预后都较差,但早期诊断和治疗对于生活质量和生存期而言至关重要。

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