Istanbul Medipol University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.
Istanbul Medipol University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.
Neurocirugia (Astur : Engl Ed). 2022 Nov-Dec;33(6):334-339. doi: 10.1016/j.neucie.2021.03.005.
Pancreatic cancer is a common gastrointestinal malignancy, and is often associated with a poor prognosis. Although liver is generally seen as a distant metastasis point, it has been shown that it can metastasize to any organ, especially the gastrointestinal tract, and approximately 0.3% of metastases are observed in spinal cord.
We report a 36-year-old woman with a prior history of pancreatic adenocarcinoma who presented to us with a thoracic intramedullary lesion and recent onset of neurological deficits. She underwent surgery with histological confirmation of a diagnosis of metastatic adenocarcinoma.
To our knowledge there is no prior report of pure intramedullary spinal cord metastasis from a pancreatic adenocarcinoma in the literature. We report the present patient in view of the rarity of intramedullary spinal cord metastasis and its clinical significance. Although intramedullary metastases are rare, they should be investigated in every patient with malignancy and progressive neurological deficit. While its general prognosis is poor regardless of the type of treatment, early diagnosis and treatment is important in terms of quality of life and survival.
胰腺癌是一种常见的胃肠道恶性肿瘤,通常预后不良。虽然肝脏通常被视为远处转移部位,但已有研究表明,它可以转移到任何器官,尤其是胃肠道,约有 0.3%的转移发生在脊髓。
我们报告了一例 36 岁的女性,既往有胰腺腺癌病史,因胸髓内病变和近期出现神经功能缺损就诊。她接受了手术治疗,组织学证实为转移性腺癌。
据我们所知,文献中尚无先前报道的胰腺腺癌单纯发生髓内脊髓转移。鉴于髓内脊髓转移罕见及其临床意义,我们报告了本病例。虽然髓内转移很少见,但对于每例有恶性肿瘤和进行性神经功能缺损的患者都应进行检查。尽管无论治疗类型如何,其总体预后均较差,但早期诊断和治疗对于提高生活质量和延长生存期非常重要。