Department of Neurology, Ina Central Hospital, Japan.
Department of Neurosurgery, Ina Central Hospital, Japan.
Intern Med. 2021 Nov 1;60(21):3473-3476. doi: 10.2169/internalmedicine.6927-20. Epub 2021 May 14.
A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT). The ACC handles working memory formation and is essential for the executive function. The areas showing a decreased activity on SPECT were responsible for the working memory, which corresponded to the observed symptoms. This is the first case in which limited ACC infarction resulted in permanent working memory dysfunction, and SPECT revealed the decreasing working memory in the associated region.
一位 52 岁男性突发全面性遗忘和左侧肢体共济失调。右侧大脑前动脉栓塞导致扣带回前部皮质（ACC）梗死，工作记忆功能障碍持续存在。单光子发射计算机断层扫描（SPECT）显示 ACC、前额叶皮质和双侧顶上小叶活性降低。ACC 负责工作记忆的形成，是执行功能的关键。SPECT 显示活性降低的区域与工作记忆有关，与观察到的症状相对应。这是首例有限的 ACC 梗死导致永久性工作记忆障碍的病例，SPECT 显示相关区域的工作记忆下降。
