Department of Cardiology, Yanbian University Hospital.
Department of Cardiology, Nagoya University Graduate School of Medicine.
Int Heart J. 2021 May 29;62(3):470-478. doi: 10.1536/ihj.20-181. Epub 2021 May 15.
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular atherosclerosis-based cardiovascular disease (ACVD). Dipeptidyl peptidase-4 (DPP-4) is a complex enzyme that acts as a membrane-anchored cell surface exopeptidase. DPP-4 is upregulated in metabolic and inflammatory cardiovascular disorders. DPP-4 exhibits many physiological and pharmacological functions by regulating its extremely abundant substrates, such as glucagon-like peptide-1 (GLP-1). Over the last 10 years, emerging data have demonstrated unexpected roles of DPP-4 in extracellular and intracellular signaling, immune activation, inflammation, oxidative stress production, cell apoptosis, insulin resistance, and lipid metabolism. This mini-review focuses on recent novel findings in this field, highlighting a DPP-4-mediated regulation of GLP-1-dependent and -independent signaling pathways as a potential therapeutic molecular target in treatments of chronic psychological stress-related ACVD in humans and animals.
暴露于心理社会压力是心血管疾病的一个风险因素，包括基于血管动脉粥样硬化的心血管疾病（ACVD）。二肽基肽酶-4（DPP-4）是一种复杂的酶，作为一种膜锚定的细胞表面外肽酶发挥作用。在代谢和炎症性心血管疾病中，DPP-4 上调。DPP-4 通过调节其极其丰富的底物，如胰高血糖素样肽-1（GLP-1），表现出许多生理和药理功能。在过去的 10 年中，新出现的数据表明 DPP-4 在细胞外和细胞内信号转导、免疫激活、炎症、氧化应激产生、细胞凋亡、胰岛素抵抗和脂质代谢中的作用出乎意料。这篇小型综述重点介绍了该领域的最新新发现，强调了 DPP-4 介导的 GLP-1 依赖和不依赖的信号通路调节，作为人类和动物慢性心理应激相关 ACVD 治疗的潜在治疗性分子靶点。
