抗体催化立体特异性双分子酰胺合成。
Catalysis of a stereospecific bimolecular amide synthesis by an antibody.
作者信息
Benkovic S J, Napper A D, Lerner R A
机构信息
Department of Chemistry, Pennsylvania State University, University Park 16802.
出版信息
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5355-8. doi: 10.1073/pnas.85.15.5355.
Abstract
We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.
摘要
我们报道了一种由抗体催化的非水解双分子氨解反应。外消旋内酯与芳香胺形成酰胺的立体特异性反应由随机平衡双反应物动力学序列描述。观察到的周转率可以通过测量反应物与过渡态类似物结合之间的差异来近似估算。
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