剖析长链非编码RNA在脑室周围白质损伤发展中的作用
Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage.
作者信息
Wang Xinyu, Liu Heng, Liao Xiaoli, Qiao Lixing, Zhu Lihua, Wu Shun, Zhou Yan, Zhang Yi, Li Bangbang, Lin Lili, Ma Jingjing, Gu Qianying, Shu Jiaping
机构信息
Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China.
Institute of Clinical, Jiangsu Health Vocational College, Nanjing, China.
出版信息
Front Genet. 2021 Apr 30;12:641526. doi: 10.3389/fgene.2021.641526. eCollection 2021.
Long non-coding RNA (LncRNA) has high expression in the brain. Animal studies have shown that lncRNA plays an important role in brain functions and mediates the development of many neurological diseases. However, data on the expression of lncRNAs and the clinical significance in prematurely born infants with diseases such as periventricular white matter damage (PWMD) remains scant. Here, we compared the expression of the lncRNAs in whole blood samples obtained from prematurely born infants with PWMD with samples from prematurely born infants without PWMD. Our data demonstrated differential expression of the lncRNAs between the two groups. Further, we showed that the lncRNAs play important roles in the development of PWMD. Our findings give insights into the functions of the lncRNAs in PWMD and provide evidence for the improvement of diagnostic and treatment strategies in infants with PWMD.
长链非编码RNA（LncRNA）在大脑中高表达。动物研究表明，LncRNA在脑功能中起重要作用，并介导多种神经疾病的发展。然而，关于LncRNAs在患有脑室周围白质损伤（PWMD）等疾病的早产儿中的表达及其临床意义的数据仍然很少。在此，我们比较了患有PWMD的早产儿全血样本与未患有PWMD的早产儿样本中LncRNAs的表达。我们的数据表明两组之间LncRNAs存在差异表达。此外，我们表明LncRNAs在PWMD的发展中起重要作用。我们的研究结果为深入了解LncRNAs在PWMD中的功能提供了见解，并为改善PWMD婴儿的诊断和治疗策略提供了证据。
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