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药物使用管理政策对佐治亚州医疗补助计划中处方阿片类药物使用的影响。

Impact of drug utilization management policy on prescription opioid use in Georgia Medicaid.

作者信息

Wang Yu, Perri Matthew, Young Henry, Abraham Amanda, Jayawardhana Jayani

机构信息

Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Athens, GA, USA.

Department of Public Administration and Policy, School of Public & International Affairs, University of Georgia, Athens, GA, USA.

出版信息

J Pharm Health Serv Res. 2021 Jan 22;12(2):188-193. doi: 10.1093/jphsr/rmaa026. eCollection 2021 Jun.

Abstract

OBJECTIVE

To examine the effectiveness of changes in opioid prescription policies on opioid prescribing and health services utilization rates in Georgia Medicaid.

METHODS

This study used data from the Georgia Medicaid patient enrollment, medical and pharmacy claims database from 2009 to 2014.We performed an interrupted time series analysis to examine the effect of the policy changes. Outcome measures assessed the trends in the indicators of potential inappropriate prescribing practices, including overlapping prescriptions of opioid + opioid, opioid + benzodiazepine and opioids + buprenorphine/naloxone, as well as health services utilization, including hospitalization, mean length of stay, outpatient office and emergency room visits.

KEY FINDINGS

A total of 712 342 opioid users aged 18-64 were included in the study. The policies were associated with significant decreasing trend of opioid + opioid (-0.0011; 95% CI = -0.0020, -0.0002) and opioid + benzodiazepines (-0.001; 95% CI = -0.0022, -0.0006) overlapping while associated with a significant immediate decrease in and opioids + buprenorphine/naloxone after the implementations (-0.0014; 95% CI = -0.0025, -0.0003). Significant immediate decrease in level of office visits and ER visits were seen with the policy implementation (office visit: -0.2939; 95% CI = -0.5528, -0.0350, ER visit: -0.0740, 95% CI = -0.1294, -0.0185). The policies were not shown to be significantly associated with hospitalization and the mean length of inpatient stay.

CONCLUSIONS

Our analysis suggests that Georgia Medicaid opioid policies were useful to contain inappropriate opioid use.

摘要

目的

研究阿片类药物处方政策的变化对佐治亚州医疗补助计划中阿片类药物处方及医疗服务利用率的影响。

方法

本研究使用了佐治亚州医疗补助计划2009年至2014年患者登记、医疗和药房报销数据库中的数据。我们进行了中断时间序列分析,以研究政策变化的影响。结果指标评估了潜在不适当处方行为指标的趋势,包括阿片类药物+阿片类药物、阿片类药物+苯二氮卓类药物和阿片类药物+丁丙诺啡/纳洛酮的重复处方,以及医疗服务利用率,包括住院、平均住院时间、门诊和急诊就诊次数。

主要发现

本研究共纳入712342名18至64岁的阿片类药物使用者。这些政策与阿片类药物+阿片类药物(-0.0011;95%可信区间=-0.0020,-0.0002)和阿片类药物+苯二氮卓类药物(-0.001;95%可信区间=-0.0022,-0.0006)重复处方的显著下降趋势相关,同时与实施后阿片类药物+丁丙诺啡/纳洛酮的显著即刻下降相关(-0.0014;95%可信区间=-0.0025,-0.0003)。政策实施后,门诊就诊和急诊就诊次数显著即刻下降(门诊就诊:-0.2939;95%可信区间=-0.5528,-0.0350,急诊就诊:-0.0740,95%可信区间=-0.1294,-0.0185)。这些政策未显示与住院及住院平均时间有显著关联。

结论

我们的分析表明,佐治亚州医疗补助计划的阿片类药物政策有助于遏制不适当的阿片类药物使用。

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