Callanan M M, Logsdail S J, Ron M A, Warrington E K
National Hospital for Nervous Diseases, London.
Brain. 1989 Apr;112 ( Pt 2):361-74. doi: 10.1093/brain/112.2.361.
This study reports the performance on psychometric tests of a group of 48 patients with clinically isolated lesions of the type seen in multiple sclerosis (optic neuritis, brainstem and cord lesions). The cognitive functions studied were: 'IQ deficit', verbal and visual memory, abstracting ability, visual and auditory attention, and naming ability. The presence of brain pathology was investigated by means of magnetic resonance imaging (MRI). A group of 46 patients with rheumatic and neurological conditions not known to cause brain disease was used for comparison. Normative MRI data were obtained from a group of 40 normal volunteers. An overall 'Cognitive Ability Index' was significantly worse in patients with clinically isolated lesions when compared with physically disabled controls. IQ deficit and defective auditory attention were the more severely affected parameters. These deficits were significantly correlated with the duration of neurological symptoms and with the degree of brain pathology detected by MRI.
本研究报告了一组48例患有多发性硬化症中所见类型的临床孤立性病变（视神经炎、脑干和脊髓病变）患者的心理测量测试表现。所研究的认知功能包括：“智商缺陷”、言语和视觉记忆、抽象能力、视觉和听觉注意力以及命名能力。通过磁共振成像（MRI）研究脑部病变的存在情况。将一组46例患有风湿性和神经疾病但未知会导致脑部疾病的患者作为对照。从一组40名正常志愿者中获取了MRI规范数据。与身体残疾的对照组相比，临床孤立性病变患者的总体“认知能力指数”明显更差。智商缺陷和听觉注意力缺陷是受影响更严重的参数。这些缺陷与神经症状的持续时间以及MRI检测到的脑部病变程度显著相关。
