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泊沙康唑缓释片成功用于治疗一头宽吻海豚幼崽疑似毛霉菌病。

The use of posaconazole delayed-release tablets in the successful treatment of suspected mucormycosis in a bottlenose dolphin () calf.

作者信息

Marques Gonçalo N, Silva Nuno U, Leal Miriam O, Flanagan Carla A

机构信息

Zoomarine Portugal, N125 KM 65, 8201-864, Guia, Portugal.

出版信息

Med Mycol Case Rep. 2021 Apr 26;32:77-80. doi: 10.1016/j.mmcr.2021.04.003. eCollection 2021 Jun.

Abstract

Mucorales infections in cetaceans have a high mortality rate. This case report refers to a bottlenose dolphin calf with suspected mucormycosis treated with posaconazole. This antifungal agent was discontinued after 96 days of therapy, however, the infection relapsed. Posaconazole was then resumed for a total of 255 days, with no signs of disease reactivation. The retrospective analysis of posaconazole serum levels in this successful case showed concentrations varying between 5.18 and 11.63 mg/L.

摘要

鲸类动物的毛霉目感染死亡率很高。本病例报告涉及一头疑似患有毛霉病的宽吻海豚幼崽,使用泊沙康唑进行治疗。在治疗96天后停用了这种抗真菌药物,然而,感染复发。随后重新使用泊沙康唑,总共使用了255天,没有疾病再次激活的迹象。对这个成功病例中泊沙康唑血清水平的回顾性分析显示,浓度在5.18至11.63毫克/升之间变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec0/8102706/786646f8be77/gr1.jpg

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