评估两种生物制剂局部应用于治疗儿童化疗引起的口腔黏膜炎的效果：一项随机临床试验。
Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial.
作者信息
Alkhouli Muaaz, Laflouf Mohannad, Comisi John C
机构信息
Department of Pediatric Dentistry, Faculty of Dentistry, Damascus University, PO Box 30621, Damascus, Syria.
Department of Oral Rehabilitation, Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Ave, BSB 548, MSC 507, Charleston, SC, 29425, USA.
出版信息
J Oral Biol Craniofac Res. 2021 Jul-Sep;11(3):373-378. doi: 10.1016/j.jobcr.2021.04.001. Epub 2021 Apr 12.
BACKGROUND
oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis.
METHODS
36 children between 6 and 9 years and suffering from grade 3 or 4 oral mucositis, according to the World Health Organization (W.H.O.) scale, were enrolled in this clinical trial. Participants were separated into three groups to treat their mucositis using Aloe Vera, Olive Oil, or sodium bicarbonate. Nurses administrated the agents four times daily with sponge sticks. Two blinded investigators examined the oral mucosa after ten days.
RESULTS
Both Aloe Vera and Olive Oil significant differences in the management of chemotherapy-induced oral mucositis compared to sodium bicarbonate treatments.
CONCLUSIONS
Olive Oil is effective in managing CIOM.
背景
口腔黏膜炎是化疗最令人烦恼的并发症之一。这项随机临床试验旨在评估芦荟和橄榄油在治疗化疗引起的口腔黏膜炎方面的效果。
方法
根据世界卫生组织（WHO）的标准，36名6至9岁且患有3级或4级口腔黏膜炎的儿童参加了这项临床试验。参与者被分为三组，分别使用芦荟、橄榄油或碳酸氢钠治疗口腔黏膜炎。护士每天用海绵棒给药四次。两名盲法研究者在十天后检查口腔黏膜。
结果
与碳酸氢钠治疗相比，芦荟和橄榄油在治疗化疗引起的口腔黏膜炎方面均有显著差异。
结论
橄榄油在治疗化疗引起的口腔黏膜炎方面有效。
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