Dipalma Gianna, Inchingolo Angelo Michele, Latini Giulia, Ferrante Laura, Nardelli Paola, Malcangi Giuseppina, Trilli Irma, Inchingolo Francesco, Palermo Andrea, Inchingolo Alessio Danilo
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
College of Medicine and Dentistry, Birmingham B4 6BN, UK.
Antioxidants (Basel). 2024 Sep 25;13(10):1160. doi: 10.3390/antiox13101160.
Chemotherapy (CT) and radiation therapy (RT), while effective against cancer, often cause severe side effects, such as oral mucositis and other oral diseases. Oral mucositis, characterized by inflammation and ulceration of the oral mucosa, is one of the most painful side effects that can reduce quality of life and limit cancer treatment. Curcumin, a polyphenol from , has garnered attention for its anti-inflammatory, antioxidant, and anti-carcinogenic properties, which protect the oral mucosa by reducing oxidative stress and modulating inflammation. This study reviews the therapeutic potential of curcumin in preventing and managing oral mucositis caused by CT and RT. Clinical trials show curcumin's effectiveness in reducing the incidence and severity of oral mucositis. Although curcumin supplementation appears to be a promising and cost-effective approach for mitigating oral complications in cancer patients, further clinical trials are needed to confirm its efficacy and optimize dosing strategies.
化疗（CT）和放射治疗（RT）虽然对癌症有效，但往往会引起严重的副作用，如口腔黏膜炎和其他口腔疾病。口腔黏膜炎以口腔黏膜的炎症和溃疡为特征，是最痛苦的副作用之一，会降低生活质量并限制癌症治疗。姜黄素是一种来自[具体来源未提及]的多酚，因其抗炎、抗氧化和抗癌特性而受到关注，这些特性通过减少氧化应激和调节炎症来保护口腔黏膜。本研究综述了姜黄素在预防和管理由CT和RT引起的口腔黏膜炎方面的治疗潜力。临床试验表明姜黄素在降低口腔黏膜炎的发生率和严重程度方面是有效的。尽管补充姜黄素似乎是减轻癌症患者口腔并发症的一种有前景且具有成本效益的方法，但仍需要进一步的临床试验来证实其疗效并优化给药策略。
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