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转移性生殖细胞癌的外科治疗

Surgical treatment of metastatic germ cell cancer.

作者信息

Hiester Andreas, Albers Peter

机构信息

Department of Urology, University of Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.

出版信息

Asian J Urol. 2021 Apr;8(2):155-160. doi: 10.1016/j.ajur.2020.05.007. Epub 2020 Jun 1.

Abstract

Among young men between the ages of 15 and 40 years, germ cell cancer is the most common solid tumor [1]. The worldwide incidence of germ cell cancer is 70 000 cases. Compared to all solid tumors of men, germ cell cancer accounts for 1% of all male tumors. Nevertheless, the mortality of this rare tumor entity is about 13% since 9507 patients died worldwide of germ cell cancer. The improvement in survival of germ cell cancer patients is due to a multimodal treatment of germ cell cancer including cisplatin-based chemotherapy and surgery leading to higher cure-rates even in advanced stages [1], whereas the increasing incidence of germ cell cancers cannot be thoroughly explained. In this article we review the current indications for surgery in metastatic germ cell cancers, highlight the strength and weaknesses of techniques and indications and raise the question how to improve surgical treatment in metastatic germ cell cancer.

摘要

在15至40岁的年轻男性中,生殖细胞癌是最常见的实体瘤[1]。全球生殖细胞癌的发病率为7万例。与男性所有实体瘤相比,生殖细胞癌占所有男性肿瘤的1%。然而,这种罕见肿瘤实体的死亡率约为13%,因为全球有9507例患者死于生殖细胞癌。生殖细胞癌患者生存率的提高归因于生殖细胞癌的多模式治疗,包括以顺铂为基础的化疗和手术,即使在晚期也能提高治愈率[1],而生殖细胞癌发病率的上升则无法得到充分解释。在本文中,我们回顾了转移性生殖细胞癌手术的当前适应证,强调了技术和适应证的优缺点,并提出了如何改善转移性生殖细胞癌手术治疗的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d4/8099653/f50e3c574e86/gr1.jpg

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